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GlossaryMinoxidil 5% (5% Minoxidil Solution)

topical solution used to treat hair loss and promote regrowth

Minoxidil 5% is a topical medication commonly used to treat hair loss and promote hair regrowth in conditions like androgenetic alopecia. It works by stimulating hair follicles and increasing blood flow to the scalp, which can help to extend the growth phase of hair. This concentration is often marketed under brand names like Rogaine and is available over-the-counter.

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Research

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research A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss

219 citations, March 2004 in “Journal of The American Academy of Dermatology”

5% and 2% minoxidil solutions effectively promote hair growth and reduce hair loss, with 5% being slightly more effective but having more side effects.

A Randomized, Single-Blind Trial of 5% Minoxidil Foam Once Daily Versus 2% Minoxidil Solution Twice Daily in the Treatment of Androgenetic Alopecia in Women

research A Randomized, Single-Blind Trial of 5% Minoxidil Foam Once Daily Versus 2% Minoxidil Solution Twice Daily in the Treatment of Androgenetic Alopecia in Women

100 citations, June 2011 in “Journal of The American Academy of Dermatology”

5% minoxidil foam once daily works as well as 2% minoxidil solution twice daily for female hair growth and is more convenient.

Comparison of QR 678 and QR 678 Neo as Monotherapy and Combination Therapy with 5% Minoxidil Solution and Oral Finasteride in the Treatment of Male Androgenetic Alopecia—Which Is Better?

research Comparison of QR 678 and QR 678 Neo as Monotherapy and Combination Therapy with 5% Minoxidil Solution and Oral Finasteride in the Treatment of Male Androgenetic Alopecia—Which Is Better?

3 citations, April 2021 in “Journal of Cosmetic Dermatology”

Combination therapy with QR 678 Neo and 5% Minoxidil is most effective for male hair loss.

research Efficacy and Safety of Minoxidil 5% Foam in Combination With a Botanical Hair Solution in Men With Androgenic Alopecia

3 citations, April 2016 in “PubMed”

Using Minoxidil 5% foam with a botanical hair solution twice daily can significantly improve hair growth and appearance in men with hair loss, and is generally well-tolerated.

Generalized Hypertrichosis After 5% Minoxidil Solution in Trichorhinophalangeal Syndrome: A Case Report and Review of the Literature

research Generalized Hypertrichosis After 5% Minoxidil Solution in Trichorhinophalangeal Syndrome: A Case Report and Review of the Literature

1 citations, January 2023 in “Indian Journal of Dermatology/Indian journal of dermatology”

5% minoxidil can significantly increase hair growth in TRPS patients.

research Comparative Clinical Assessment of 5% Minoxidil Topical Application with Supplemental Intradermal Meso-Solution Administration for the Management of Androgenetic Alopecia in Men

January 2021 in “Indian journal of drugs in dermatology”

Combining minoxidil with MS injections leads to better hair regrowth in men.

Faculty Opinions Recommendation of a Randomized, Single-Blind Trial of 5% Minoxidil Foam Once Daily Versus 2% Minoxidil Solution Twice Daily in the Treatment of Androgenetic Alopecia in Women

research Faculty Opinions Recommendation of a Randomized, Single-Blind Trial of 5% Minoxidil Foam Once Daily Versus 2% Minoxidil Solution Twice Daily in the Treatment of Androgenetic Alopecia in Women

August 2011 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

5% minoxidil foam used once daily is as effective as 2% minoxidil solution used twice daily for hair loss in women, but with fewer side effects like itching and dandruff.

Platelet-Rich Plasma in Combination With 5% Minoxidil Topical Solution and 1 mg Oral Finasteride for the Treatment of Androgenetic Alopecia: A Randomized Placebo-Controlled, Double-Blind, Half-Head Study

research Platelet-Rich Plasma in Combination With 5% Minoxidil Topical Solution and 1 mg Oral Finasteride for the Treatment of Androgenetic Alopecia: A Randomized Placebo-Controlled, Double-Blind, Half-Head Study

19 citations, May 2017 in “Dermatologic Surgery”

Combining platelet-rich plasma with 5% minoxidil solution improves hair regrowth in androgenetic alopecia patients.

Efficacy and Safety of a Novel Herbal Solution for the Treatment of Androgenetic Alopecia and Comparison with 5% Minoxidil: A Double-Blind, Randomized Controlled Trial Study

research Efficacy and Safety of a Novel Herbal Solution for the Treatment of Androgenetic Alopecia and Comparison with 5% Minoxidil: A Double-Blind, Randomized Controlled Trial Study

2 citations, October 2020 in “Dermatologic Therapy”

Herbal solution improves hair diameter and density more than 5% minoxidil for androgenetic alopecia.

research Trichoscan: Results Using a 5% Minoxidil Topical Solution in Men with Androgenetic Alopecia

March 2004 in “Journal of The American Academy of Dermatology”

Minoxidil solution increases hair growth; Shampoo B best for dandruff; infliximab helps pemphigus vulgaris.

Efficacy, Tolerability, and Superiority of Propylene Glycol-Free, North American Witch-Hazel-Based Solution of 5% Minoxidil Sulfate for the Treatment of Female Androgenetic Alopecia

research Efficacy, Tolerability, and Superiority of Propylene Glycol-Free, North American Witch-Hazel-Based Solution of 5% Minoxidil Sulfate for the Treatment of Female Androgenetic Alopecia

May 2023 in “International Journal of Trichology”

A witch-hazel-based 5% minoxidil solution is effective and safe for women with hair loss who didn't respond to regular minoxidil, especially if they're sensitive to propylene glycol.

Comparative Study to Evaluate Tolerability of Topical 5% Minoxidil Novel Formulation and Alcohol-Based Conventional Solutions in Treatment of Androgenetic Alopecia in Indian Men: Randomized Double-Blind Study

research Comparative Study to Evaluate Tolerability of Topical 5% Minoxidil Novel Formulation and Alcohol-Based Conventional Solutions in Treatment of Androgenetic Alopecia in Indian Men: Randomized Double-Blind Study

April 2020 in “Dermatology and therapy”

New 5% minoxidil solution improves scalp hydration, reduces redness, and may be safer for sensitive users.

research Topical Minoxidil Solution (1% and 5%) in the Treatment of Alopecia Areata

101 citations, March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil solution helps hair regrowth in alopecia areata, with 5% being more effective.

A Pilot Study of the Efficacy in Treatment of Female Pattern Hair Loss Using 5% Minoxidil Solution Combined with Oral Chelated Zinc Supplement

research A Pilot Study of the Efficacy in Treatment of Female Pattern Hair Loss Using 5% Minoxidil Solution Combined with Oral Chelated Zinc Supplement

2 citations, January 2014 in “Hair therapy & transplantation”

Using 5% Minoxidil solution with oral chelated zinc supplement can effectively treat female pattern hair loss.

A Comparative Study Between the Efficacy and Safety of 5% Minoxidil Solution and 5% Minoxidil Milky Lotion in the Treatment of Male Androgenic Alopecia

research A Comparative Study Between the Efficacy and Safety of 5% Minoxidil Solution and 5% Minoxidil Milky Lotion in the Treatment of Male Androgenic Alopecia

January 2017 in “PubMed”

Both 5% minoxidil solution and milky lotion effectively and safely treat male hair loss, with the lotion being a good alternative for those sensitive to certain ingredients.

research Comparison Between 5% Minoxidil Plus 2% Flutamide Solution vs. 5% Minoxidil Solution in the Treatment of Androgenetic Alopecia

February 2022 in “Journal of Cosmetic Dermatology”

Using both minoxidil and flutamide together is more effective for treating hair loss than using minoxidil alone.

Randomized Trial of Electrodynamic Microneedling Combined with 5% Minoxidil Topical Solution for Treating Androgenetic Alopecia in Chinese Males and Molecular Mechanistic Study of the Involvement of the Wnt/β-Catenin Signaling Pathway

research Randomized Trial of Electrodynamic Microneedling Combined with 5% Minoxidil Topical Solution for Treating Androgenetic Alopecia in Chinese Males and Molecular Mechanistic Study of the Involvement of the Wnt/β-Catenin Signaling Pathway

10 citations, May 2020 in “Journal of Dermatological Treatment”

Microneedling with 5% minoxidil improves hair loss in Chinese men by activating Wnt/ß-catenin pathway.

research Efficacy and Safety of Once-Daily Minoxidil Foam 5% Versus Twice-Daily Minoxidil Solution 2% in Female Pattern Hair Loss: A Phase III, Randomized, Investigator-Blinded Study

1 citations, July 2016 in “PubMed”

Once-daily 5% minoxidil foam and twice-daily 2% minoxidil solution are similarly effective and safe for female pattern hair loss.

research Efficacy and Safety of Topical 5% Azelaic Acid Solution Versus 2% Minoxidil Solution in the Treatment of Female Pattern Hair Loss

December 2023 in “Siriraj Medical Journal”

5% Azelaic acid is as effective as 2% Minoxidil for female pattern hair loss and could be an alternative for those allergic to Minoxidil or pregnant.

Efficacy and Safety of Once-Daily Minoxidil Foam 5% Versus Twice-Daily Minoxidil Solution 2% in Female Pattern Hair Loss: A Phase III, Randomized, Investigator-Blinded Study

research Efficacy and Safety of Once-Daily Minoxidil Foam 5% Versus Twice-Daily Minoxidil Solution 2% in Female Pattern Hair Loss: A Phase III, Randomized, Investigator-Blinded Study

September 2016 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Once-daily 5% minoxidil foam increases hair regrowth and density in women with hair loss, but not as effectively as twice-daily 2% minoxidil solution, though it's safer and more convenient.

research Minoxidil 1 mg Oral Versus Minoxidil 5% Topical Solution for the Treatment of Female-Pattern Hair Loss: A Randomized Clinical Trial

53 citations, August 2019 in “Journal of The American Academy of Dermatology”

Oral minoxidil and topical minoxidil 5% both effectively improve female-pattern hair loss with safe side effects.

research Frontal Edema Due to Topical Application of 5% Minoxidil Solution Following Mesotherapy Injections

7 citations, January 2015 in “International Journal of Trichology”

Applying minoxidil on the scalp after mesotherapy injections caused temporary swelling.

research An Open Label, Multi-Center Clinical Trial of Topical 5% Minoxidil Solution for the Treatment of Male Androgenetic Alopecia (A Phase IV Study)

2 citations, March 2009 in “Journal of Clinical Dermatology”

research Comparison of the Efficacy and Safety of Topical 5% Minoxidil Solution Alone and in Combination with 0.05% Betamethasone Dipropionate Cream in the Treatment of Alopecia Areata

January 2010 in “Annals of King Edward Medical University”

The combination of minoxidil and betamethasone is more effective for hair regrowth than minoxidil alone.

Comparing the Effectiveness of Local Solution of Minoxidil and Caffeine 2.5% with Local Solution of Minoxidil 2.5% in Treatment of Androgenetic Alopecia

research Comparing the Effectiveness of Local Solution of Minoxidil and Caffeine 2.5% with Local Solution of Minoxidil 2.5% in Treatment of Androgenetic Alopecia

November 2013 in “Journal of Mazandaran University of Medical Sciences”

Minoxidil with caffeine works better for hair loss than minoxidil alone.

research Dermoscopic Evaluation of the Efficacy of Combination of Topical Spironolactone 5% and Minoxidil 5% Solutions in the Treatment of Androgenetic Alopecia: A Cross-Sectional Comparative Study

1 citations, August 2022 in “Journal of Cosmetic Dermatology”

Using both 5% spironolactone and 5% minoxidil together is safe and more effective for treating hair loss.

research Comparison of the Efficacy of Topical Minoxidil 5% and Adenosine 0.75% Solutions on Male Androgenetic Alopecia and Measuring Patient Satisfaction Rate

1 citations, January 2013 in “PubMed”

Adenosine led to higher patient satisfaction than minoxidil for hair loss treatment.

research Dermoscopic Evaluation of the Efficacy of Combination of Topical Spironolactone 5% and Minoxidil 5% Solutions in the Treatment of Androgenetic Alopecia, Comparative Study

November 2022 in “Al-Azhar International Medical Journal (Print)”

Combining 5% spironolactone and 5% minoxidil is safe and more effective for treating hair loss.

Comparison of the Therapeutic Effects of Minoxidil 5% Solution Alone with Flutamide 2% and Minoxidil 5% Mixed Solution in Patients with Androgenetic Alopecia Referring to Dermatology Clinic of Isfahan University of Medical Sciences

research Comparison of the Therapeutic Effects of Minoxidil 5% Solution Alone with Flutamide 2% and Minoxidil 5% Mixed Solution in Patients with Androgenetic Alopecia Referring to Dermatology Clinic of Isfahan University of Medical Sciences

May 2021 in “medical journal of mashhad university of medical sciences”

The mix of 2% flutamide and 5% minoxidil improves hair thickness more than just 5% minoxidil alone in treating hair loss.

Comparative Clinical Study Evaluating the Efficacy and Safety of Topical 5% Cetosomal Minoxidil and Topical 5% Alcohol-Based Minoxidil Solutions for the Treatment of Androgenetic Alopecia in Indian Men

research Comparative Clinical Study Evaluating the Efficacy and Safety of Topical 5% Cetosomal Minoxidil and Topical 5% Alcohol-Based Minoxidil Solutions for the Treatment of Androgenetic Alopecia in Indian Men

October 2023 in “Cureus”

Cetosomal minoxidil is safer and as effective as alcohol-based minoxidil for male hair loss treatment.