Generalized Hypertrichosis After 5% Minoxidil Solution in Trichorhinophalangeal Syndrome: A Case Report and Review of the Literature

January 2023 in “ Indian Journal of Dermatology/Indian journal of dermatology ”

Bong Seok Shin, Jun Ho Kwak, Hyo-Sang Choi, Chan Ho Na, Min Sung Kim

minoxidil 5% minoxidil solution generalized hypertrichosis Trichorhinophalangeal syndrome TRPS type I Wnt signaling hair growth scalp hypertrichosis Rogaine

Studysummary This case study reported that 5% minoxidil solution effectively promoted hair growth and resulted in generalized hypertrichosis in a 7-year-old with Trichorhinophalangeal syndrome type I.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

A 7-year-old female with Trichorhinophalangeal syndrome (TRPS) type I, characterized by distinctive facial features and sparse hair, was treated with 5% minoxidil solution. After 9 months, she showed significant hair growth not only on the scalp but also in areas where minoxidil was not applied, indicating generalized hypertrichosis. This case suggests that minoxidil may activate Wnt signaling, which is typically down-regulated in TRPS type I, leading to improved hair growth. Despite hypertrichosis being a common side effect, the patient was satisfied with the results. The authors recommend 5% minoxidil as a treatment option for hair loss in TRPS patients.

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3 / 3 results

research Minoxidil: A Comprehensive Review

16 citations , June 2021 in “Journal of Dermatological Treatment”

This study reported that while topical minoxidil exhibits hair regrowth in androgenetic alopecia, oral minoxidil 5 mg/day was more effective than topical forms after six months, with low doses also potentially effective for women and other hair loss types.

TRPS1 Mutation Associated with Trichorhinophalangeal Syndrome Type 1 with 15 Supernumerary Teeth, Hypoplastic Mandibular Condyles with Slender Condylar Necks and Unique Hair Morphology

research TRPS1 Mutation Associated with Trichorhinophalangeal Syndrome Type 1 with 15 Supernumerary Teeth, Hypoplastic Mandibular Condyles with Slender Condylar Necks and Unique Hair Morphology

9 citations , April 2020 in “Journal of dermatology”

This case report describes a Thai male with TRPS1 who exhibited unique and unreported features such as hypoplastic mandibular condyles, double mental foramina, and distinctive hair abnormalities.

research Diffuse Hypertrichosis During Treatment with 5% Topical Minoxidil

44 citations , January 1997 in “British Journal of Dermatology”

In this study, five women with androgenetic alopecia experienced severe facial and limb hypertrichosis after using 5% topical minoxidil, which resolved after discontinuing the treatment.