Generalized Hypertrichosis After 5% Minoxidil Solution in Trichorhinophalangeal Syndrome: A Case Report and Review of the Literature

A 7-year-old female with Trichorhinophalangeal syndrome (TRPS) type I, characterized by distinctive facial features and sparse hair, was treated with 5% minoxidil solution. After 9 months, she showed significant hair growth not only on the scalp but also in areas where minoxidil was not applied, indicating generalized hypertrichosis. This case suggests that minoxidil may activate Wnt signaling, which is typically down-regulated in TRPS type I, leading to improved hair growth. Despite hypertrichosis being a common side effect, the patient was satisfied with the results. The authors recommend 5% minoxidil as a treatment option for hair loss in TRPS patients.