Search

for
Search:

Did you mean 4-azasteroid?

Glossary4-azasteroid

synthetic compound mimicking steroids with a nitrogen atom

A 4-azasteroid is a type of synthetic compound that mimics the structure of steroids but includes a nitrogen atom at the fourth position in its chemical structure. These compounds are often used in medical treatments to inhibit enzymes like 5-alpha-reductase, which can help manage conditions such as benign prostatic hyperplasia and androgenic alopecia (hair loss).

Related Terms

Sort by

Research

30 / 1000+ results

research Azasteroids as Inhibitors of Testosterone 5α-Reductase in Mammalian Skin

34 citations, February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

5 citations, February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Four-Amino Acid Segment in Steroid 5 Alpha-Reductase 1 Confers Sensitivity to Finasteride, a Competitive Inhibitor

83 citations, April 1992 in “Journal of Biological Chemistry”

Four-amino acid part makes enzyme sensitive to finasteride.

research Steroid 5α-Reductase Inhibitors

42 citations, May 2003 in “Mini-reviews in Medicinal Chemistry”

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

research Treatment of Hirsutism with 5α-Reductase Inhibitors

28 citations, May 1986 in “Clinics in endocrinology and metabolism”

New compounds may soon be tested to treat excessive hair growth in women.

research Dutasteride in Androgenetic Alopecia: An Update

27 citations, March 2017 in “Current Clinical Pharmacology”

Dutasteride is becoming a popular hair loss treatment, proving more effective than finasteride with similar side effects.

research 5α-Reductase Inhibitors and Prostatic Disease

21 citations, August 1994 in “Clinical endocrinology”

5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.

research Novel Inhibitors of 5α-Reductase

20 citations, February 2002 in “Expert Opinion on Therapeutic Patents”

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

research 5α-Reductase Inhibitors: Chemical and Clinical Models

17 citations, May 1998 in “Steroids”

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

research A Connection Between the Mitochondrial Permeability Transition Pore, Autophagy, and Cerebral Amyloidogenesis

14 citations, May 2008 in “Journal of proteome research”

Dutasteride may help reduce brain plaque linked to Alzheimer's by affecting cell energy structures and waste removal.

research Alopecia: The Search for Novel Agents Continues

11 citations, August 1997 in “Expert Opinion on Therapeutic Patents”

Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.

research Recent Advances in Drug Design and Drug Discovery for Androgen-Dependent Diseases

11 citations, February 2016 in “Current Medicinal Chemistry”

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

research Pharmacodynamic Modeling of Finasteride, a 5 Alpha-Reductase Inhibitor

7 citations, July 1995 in “PubMed”

Finasteride, a drug that changes testosterone to a different hormone, was studied and its effects over time were modeled successfully.

research Formulation and Evaluation of Finasteride Sustained-Release Matrix Tablets Using Different Rate Controlling Polymers

3 citations, December 2016 in “Universal journal of pharmaceutical research”

Finasteride, a drug used for anti-hyperplasia, can be effectively delivered in the form of matrix tablets.

research Synthesis of N-Substituted 3-Oxo-17b-Carboxamide-4-Aza-5a-Androstanes and the Tautomerism of 3-Oxo-4-Aza-5-Androstenes

4 citations, January 1998 in “Heterocycles”

Researchers made two new compounds that could be used for medicine.

research Crystal Structure of 3-Oxo-4-Aza-5-Alpha-Androstone-17 β-Tert-Butyl Carboxamide with an O···H–(C, N) Acceptor Four-Center Hydrogen Bond

2 citations, December 2008 in “Journal of Chemical Crystallography”

The research shows that hydrogen bonds greatly affect the crystal structure of a Finasteride derivative.

Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

research Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

12 citations, April 1995 in “Journal of Medicinal Chemistry”

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

research New Approach to 3-Oxo-4-Aza-5α-Androst-1-Ene-17β-(N-Tert-Butylcarboxamide)

14 citations, May 2005 in “Steroids”

A new method was developed to make finasteride for treating hair loss.

research Generation of Comparative Pharmacophoric Model for Steroidal 5α-Reductase I and II Inhibitors: A 3D-QSAR Study on 6-Azasteroids

13 citations, January 2015 in “Steroids”

The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.

In Vitro and In Vivo Effects of 17β-N-(4-Phenylcarbamoyl) Androst-4-en-3-one Derivatives as 5α-Reductase Inhibitors on Androgen-Dependent Glands

research In Vitro and In Vivo Effects of 17β-N-(4-Phenylcarbamoyl) Androst-4-en-3-one Derivatives as 5α-Reductase Inhibitors on Androgen-Dependent Glands

September 2020 in “Current Enzyme Inhibition”

Three compounds were found to inhibit a prostate disease-related enzyme and reduce prostate size more effectively than the current treatment, suggesting they could be used for treating benign prostatic hyperplasia.

research The Enzyme and Inhibitors of 4-Ene-3-Oxosteroid 5α-Oxidoreductase

64 citations, June 1995 in “Steroids”

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear

research Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear

10 citations, August 1998 in “Journal of Investigative Dermatology”

The compounds tested could potentially treat hair loss and alopecia.

research Evaluation of New Pregnane Derivatives as 5α-Reductase Inhibitors

23 citations, January 2001 in “Chemical & Pharmaceutical Bulletin”

New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.

research New Progesterone Esters as 5α-Reductase Inhibitors

22 citations, January 2001 in “Chemical & Pharmaceutical Bulletin”

Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.

Selective Induction of Apoptosis in the Hamster Flank Sebaceous Gland Organ by a Topical Liposome 5-Alpha-Reductase Inhibitor: A Treatment Strategy for Acne

research Selective Induction of Apoptosis in the Hamster Flank Sebaceous Gland Organ by a Topical Liposome 5-Alpha-Reductase Inhibitor: A Treatment Strategy for Acne

8 citations, February 2010 in “Journal of Dermatology”

A topical treatment safely and effectively reduced acne by causing targeted cell death in sebaceous glands without side effects.

research Caffeic Acid N-[3,5-Bis(Trifluoromethyl)Phenyl] Amide as a Non-Steroidal Inhibitor for Steroid 5α-Reductase Type 1 Using a Human Keratinocyte Cell-Based Assay and Molecular Dynamics

December 2022 in “Scientific Reports”

Compound 4 is a promising treatment for hair loss with low toxicity.