Synthesis of N-Substituted 3-Oxo-17b-Carboxamide-4-Aza-5a-Androstanes and the Tautomerism of 3-Oxo-4-Aza-5-Androstenes

    January 1998 in “ Heterocycles ”
    Peng Xia, Zhengyu Yang, Yi Xia, Haobing Zhang, Kehua Zhang, Xun Sun, Ying Chen, Yun-qing Zheng
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    TLDR Researchers made two new compounds that could be used for medicine.
    In 1998, researchers synthesized two novel N-substituted 3-oxo-4-aza-5α-androstane derivatives with potential pharmacological applications. The first compound was synthesized with a 40.10% yield and had a melting point of 264-266 °C, while the second compound had an 81.38% yield and decomposed at 312-314 °C. Their structures were confirmed using MS, IR, and ¹H-NMR, providing a foundation for future pharmacological research. The study did not involve human subjects as it focused on chemical synthesis rather than clinical trials.
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