New Approach to 3-Oxo-4-Aza-5α-Androst-1-Ene-17β-(N-Tert-Butylcarboxamide)

    May 2005 in “ Steroids ”
    Zhong‐Ping Jiang, Jing Ye, Ling Jiang, Yunyun Zhao
    TLDR A new method was developed to make finasteride for treating hair loss.
    The document described a new, more efficient method for synthesizing finasteride, a drug used to treat benign prostatic hyperplasia, hair loss, and prevent prostate cancer. The traditional synthesis methods were complex, involving many steps and the use of expensive or toxic reagents, with an overall yield of less than 16%. The new approach utilized the Ritter reaction to introduce 17β-(N-tert-butylcarboxamide) and achieved an 18.6% overall yield from 4-androste-ene-3,17-dione in seven steps. This method was more convenient and yielded higher results compared to previous methods.
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