Pharmacodynamic Modeling of Finasteride, a 5 Alpha-Reductase Inhibitor

    July 1995 in “ PubMed ”
    Hui Ling Ko, William J. Jusko
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    TLDR Finasteride, a drug that changes testosterone to a different hormone, was studied and its effects over time were modeled successfully.
    The document from 1995 studied the pharmacodynamics of finasteride, a 4-azasteroid inhibitor of one isoenzyme of 5 alpha-reductases that converts testosterone to dihydrotestosterone (DHT). The researchers characterized the time course of DHT concentrations using a specific model. The model's parameters were kin0 = 28% change/hour, kout = 0.28 hour-1, IC50 = 0.012 ng/ml, and Emax = 0.7. The modification of a previous model with the maximum partial effect factor, Emax, was suggested to be useful in characterizing the pharmacodynamics of drugs with similar indirect mechanisms.
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