Formulation and Evaluation of Finasteride Sustained-Release Matrix Tablets Using Different Rate Controlling Polymers
December 2016
in “
Universal journal of pharmaceutical research
”
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Studysummary This study concluded that Finasteride can be effectively delivered in matrix tablets using different polymer ratios for sustained release.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study from 6 years ago aimed to develop oral controlled release matrix tablet formulations of Finasteride, a synthetic 4-azasteroid drug used in the treatment of anti-hyperplasia, with different polymer ratios. Five varieties of tablets were compressed using polymers (HPMC, EC, Eudragit RS100) in different ratios and evaluated for various physical characteristics and in vitro release studies. The formulation MT5 showed a high hardness value of 4.8±0.22 kg/cm2, and matrix tablets of batch MT1 showed maximum release of 86.42% in 10 hours. The study concluded that all formulations complied with the specifications of official pharmacopoeias and/or standard references, and Finasteride can be effectively delivered in the form of matrix tablets.
