Formulation and Evaluation of Finasteride Sustained-Release Matrix Tablets Using Different Rate Controlling Polymers

December 2016 in “ Universal journal of pharmaceutical research ”

Igwe J. Chibueze, Emenike, Oduola A R

finasteride sustained-release matrix tablets HPMC EC Eudragit RS100 Propecia

TLDR Finasteride, a drug used for anti-hyperplasia, can be effectively delivered in the form of matrix tablets.

The study from 6 years ago aimed to develop oral controlled release matrix tablet formulations of Finasteride, a synthetic 4-azasteroid drug used in the treatment of anti-hyperplasia, with different polymer ratios. Five varieties of tablets were compressed using polymers (HPMC, EC, Eudragit RS100) in different ratios and evaluated for various physical characteristics and in vitro release studies. The formulation MT5 showed a high hardness value of 4.8±0.22 kg/cm2, and matrix tablets of batch MT1 showed maximum release of 86.42% in 10 hours. The study concluded that all formulations complied with the specifications of official pharmacopoeias and/or standard references, and Finasteride can be effectively delivered in the form of matrix tablets.

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