Steroid 5α-Reductase Inhibition by Polymethoxyflavones

    August 2013 in “ 한국응용생명화학회지 ”
    Yong‐ung Kim, Jaehong Han
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    Studysummary This study found that among eleven tested polymethoxyflavones, 5-hydroxy-7,4′-dimethoxyflavone was the strongest steroid 5α-reductase inhibitor and suggests potential use for benign prostatic hyperplasia treatment.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    In the 2013 study, researchers found that certain polymethoxyflavones (PMFs) can inhibit steroid 5α-reductase, an enzyme linked to benign prostatic hyperplasia (BPH) and possibly androgenetic alopecia. Among the PMFs tested, 5-hydroxy-7,4'-dimethoxyflavone (compound 5) was the most effective, with an IC50 value of 20 µM. The study highlighted the potential of PMFs as non-steroidal treatment options for BPH, noting the importance of specific structural features for their inhibitory activity. The findings suggested that PMFs could be a basis for developing new treatments for BPH and androgenetic alopecia, warranting further research. The study was funded by the National Research Foundation of Korea.
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