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Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

research Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations , January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

In this study, TASP0382088 showed potent selective inhibition of the ALK5 receptor, significantly reducing Smad2 phosphorylation in mouse skin following topical application.

research Prooxidant and antioxidant action of 4-(4-phenoxybenzoyl)benzoic acid derivatives

2 citations , February 2004 in “Biopolymers”

This study found that 4-(4-Phenoxybenzoyl)benzoic acid derivatives may act as antioxidants by scavenging certain reactive oxygen species but exhibit prooxidant behavior under specific conditions.

research Endocrine treatment of benign prostatichypertrophy: Current concepts

11 citations , January 1991 in “Urology”

This article reviews the potential of combining antiandrogenic and antiestrogenic treatments for BPH, highlighting aromatase inhibitors, but presents no new clinical results; further research is needed.

Floral Attractants in the Black Orchid Brasiliorchis Schunkeana: Clues for Presumed Sapromyophily and Potential Antimicrobial Activity

research Floral attractants in the black orchid Brasiliorchis schunkeana (Orchidaceae, Maxillariinae): clues for presumed sapromyophily and potential antimicrobial activity

1 citations , December 2022 in “BMC Plant Biology”

This study suggests that the floral secretions of Brasiliorchis schunkeana may attract Diptera as potential pollinators, but field observations are needed to confirm this pollination syndrome.

Active Compounds With Medicinal Potential Found in Maxillariinae Benth. Representatives: A Review

research Active Compounds with Medicinal Potential Found in Maxillariinae Benth. (Orchidaceae Juss.) Representatives—A Review

January 2023 in “International Journal of Molecular Sciences”

This review discusses the biologically active compounds in Maxillariinae orchids, highlighting 62 semiochemicals with medical potential, but reports no new clinical findings.

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community EveryChem 3HP / PP30 page data vs NMR PDFs in their website : metadata mistake or document mismatch?

in Research/Science 15 upvotes 5 months ago

There is an inconsistency between the molecular weight and formula listed on EveryChem's product page and the analytical PDFs for 3HP and PP30, suggesting a possible error in the product description. Concerns are raised about EveryChem's business practices and lack of transparency in testing and manufacturing.

community I got my bloodwork done... What now?

in Update 6 upvotes 8 months ago

The user has been experiencing hair thinning despite taking finasteride and minoxidil for six months. Bloodwork suggests a vitamin D deficiency, and users recommend consulting a doctor and possibly supplementing vitamin D.

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community Grow Gorgeous Intense Hair Density Serum, 2.02 fl oz, 2-pack from Costco

1 year ago

The user is considering using "Grow Gorgeous Intense Hair Density Serum" alongside Minoxidil and is currently taking Finasteride. Some users doubt the serum's effectiveness, while others suggest it may help with hair strength and thickness, but opinions are mixed.

community I was wrong about Dutastride. Let the I told you so comments rain in.

76 upvotes 10 months ago

Switching from dutasteride to finasteride caused increased hair loss, dandruff, depression, and erectile dysfunction. The user plans to return to dutasteride, possibly with minoxidil, and is considering dosing strategies to manage side effects and regrowth.

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