5 Alpha-Reductase Inhibition by a New Synthetic Steroid (PM-9) in Cultures of Penicillium Crustosum

    January 2002 in “ PubMed ”
    Marisa Cabeza, Alexandra Quiroz, Eugene Bratoeff, Genoveva Garcı́a, Elena Ramı́rez, Eugenio Flores
    TLDR PM-9, like finasteride, may help treat certain diseases by blocking a key enzyme.
    The study investigated the inhibition of 5 alpha-reductase by a new synthetic steroid, PM-9, in cultures of Penicillium crustosum. The enzyme 5 alpha-reductase is responsible for converting testosterone to 5 alpha-dihydrotestosterone (DHT), a process linked to androgen-dependent diseases like benign prostate hyperplasia and prostate cancer. The research aimed to determine the inhibition pattern of 5 alpha-reductase by finasteride and PM-9 using Lineweaver-Burk plots. The results indicated that both finasteride and PM-9 inhibited 5 alpha-reductase in a competitive manner, with a Km value of 0.22 microM and a Vmax of 0.833 pmol of DHT/mg of mycelium/day.
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