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    Glossary 3D cell spheroids

    clusters of cells growing in three-dimensional structures

    3D cell spheroids are clusters of cells that grow in a three-dimensional structure, mimicking the natural environment of tissues more accurately than traditional two-dimensional cell cultures. These spheroids are used in research to study cell behavior, drug responses, and disease mechanisms, providing a more realistic model for biological processes and potential treatments.

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    1. 3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoting Compounds: Examples of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid (TCQA) Cells · 2022 · 2 citations
    2. 3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoting Compounds: Examples of Minoxidil and 3,4,5-Tri-O-caffeoylquinic acid (TCQA) Institutional Repositories DataBase (IRDB) · 2022
    3. Self-Organizing 3D Dermal Papilla Cell Spheroids Yield Therapeutic Extracellular Vesicles that Target Hypertrophic Scar Regression via the miR-26a-5p/CCNE2 Axis Burns & Trauma · 2025
    4. Comparative analysis of 3D and 2D cell-culturing methods in hair follicle spheroid morphogenesis and drug responsiveness Biomaterials Advances · 2025 · 1 citations
    5. In vitro biomimetic platforms featuring a perfusion system and 3D spheroid culture promote the construction of tissue-engineered corneal endothelial layers Scientific Reports · 2017 · 14 citations
    6. 1333 Spheroids cell cultures as a promising study model for hair follice regeneration Journal of Investigative Dermatology · 2018
    7. Biomedical Applications of Layer‐by‐Layer Self‐Assembly for Cell Encapsulation: Current Status and Future Perspectives Advanced Healthcare Materials · 2018 · 88 citations
    8. Biological and mechanical influence of three-dimensional microenvironment formed in microwell on multicellular spheroids composed of heterogeneous hair follicle stem cells Scientific reports · 2023 · 1 citations
    9. Methods for the isolation and 3D culture of dermal papilla cells from human hair follicles Experimental Dermatology · 2017 · 55 citations
    10. TGF-β2 and collagen play pivotal roles in the spheroid formation and anti-aging of human dermal papilla cells Aging · 2021 · 11 citations
    11. 3D bioprinting of a gelatin-alginate hydrogel for tissue-engineered hair follicle regeneration Acta Biomaterialia · 2022 · 15 citations
    12. 195 Androgen action and 3D culture conditions influence dermal papilla cells inductive properties: the role of Wnt agonists/antagonists balance Journal of Investigative Dermatology · 2016
    13. Controllable Production of Transplantable Adult Human High-Passage Dermal Papilla Spheroids Using 3D Matrigel Culture Tissue engineering. Part A · 2014 · 46 citations
    14. Fish Cell Spheroids, a Promising In Vitro Model to Mimic In Vivo Research: A Review Cells · 2024 · 5 citations
    15. Non-small cell lung carcinoma spheroid models in agarose microwells for drug response studies Lab on a Chip · 2022 · 45 citations
    16. Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroid of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration ACS Applied Materials & Interfaces · 2016 · 62 citations
    17. Microfluidic Technology for the Generation of Cell Spheroids and Their Applications Micromachines · 2017 · 125 citations
    18. Bioinspired tuning of glycol chitosan for 3D cell culture NPG Asia Materials · 2016 · 61 citations
    19. Monte Carlo simulation‐guided design for size‐tuned tumor spheroid formation in 3D printed microwells Biotechnology Progress · 2024 · 2 citations
    20. 3D spheroid culture synchronizes heterogeneous MSCs into an immunomodulatory phenotype with enhanced anti-inflammatory effects iScience · 2024 · 13 citations
    21. Notes from the Editor Emeritus Hair transplant forum international · 2015
    22. Open and Closed Structure Journal of Cellular Physiology · 1967
    23. Evaluating the Characteristics of Human Hair Follicle Dermal Papilla Cells in Aggregation Culture Procedure Biomedical and Biotechnology Research Journal (BBRJ) · 2026
    24. The Dermal Papilla and Hair Follicle Regeneration: Engineering Strategies to Improve Dermal Papilla Inductivity Stem cell biology and regenerative medicine · 2022
    25. Culture Strategy Determines the Differentiation Status of Sweat Gland Cells Cells · 2025
    26. Iris germanica L. Rhizome-Derived Exosomes Ameliorated Dihydrotestosterone-Damaged Human Follicle Dermal Papilla Cells Through the Activation of Wnt/β-Catenin Pathway International Journal of Molecular Sciences · 2025
    27. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods Skin Pharmacology and Physiology · 2020 · 35 citations
    28. Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-caffeoylquinic acid (TCQA) Research Square (Research Square) · 2021
    29. High-Throughput 3D Spheroid Production with Photocurable Polyurethane Microwell Arrays via LCD 3D Printing 2026
    30. 3D Co-Culture model of Endothelial Colony Forming Cells (ECFCs) Reverses Late Passage Adipose-derived Stem Cell Senescence for Wound Healing Research Square (Research Square) · 2020