research Synthesis of N-Substituted 3-Oxo-17b-Carboxamide-4-Aza-5a-Androstanes and the Tautomerism of 3-Oxo-4-Aza-5-Androstenes
Researchers made two new compounds that could be used for medicine.
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research PNU 157706, A Novel Dual Type I and II 5α-Reductase Inhibitor
PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.
research Cutaneous Androgen Metabolism: Basic Research And Clinical Perspectives
Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.
research Crystal Structure of 3-Oxo-4-Aza-5-Alpha-Androstone-17 β-Tert-Butyl Carboxamide with an O···H–(C, N) Acceptor Four-Center Hydrogen Bond
The research shows that hydrogen bonds greatly affect the crystal structure of a Finasteride derivative.
research Effect of Solvent on Stereoselectivity in Pd/C (Type 39K)-Catalyzed Hydrogenation of Methyl 3-Oxo-4-Aza-5-Androstene-17-Carboxylate, a Key Intermediate for Finasteride and Dutasteride
Alcoholic solvent improves selectivity in key intermediate for finasteride and dutasteride synthesis.
![Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear](/images/research/861159f1-7bd4-420c-a16b-4829458efe68/small/15592.jpg)
research Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear
The compounds tested could potentially treat hair loss and alopecia.
research Azasteroids as Inhibitors of Testosterone 5α-Reductase in Mammalian Skin
Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.
research Biosynthesis of Dihydrotestosterone by a Pathway That Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line
Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.
research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism
Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.
research Selective Induction of Apoptosis in the Hamster Flank Sebaceous Gland Organ by a Topical Liposome 5-Alpha-Reductase Inhibitor: A Treatment Strategy for Acne
A topical treatment safely and effectively reduced acne by causing targeted cell death in sebaceous glands without side effects.
research Novel Inhibitors of 5α-Reductase
New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.
research Steroid Hormones: Overview and Medical Applications
Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.
research Association of Benign Prostatic Hyperplasia with Male Pattern Baldness
Men with enlarged prostates often have more severe baldness.
research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque
Testosterone can slow hair growth in adult monkeys, but a blocker called RU 58841 can counteract this and potentially help hair regrow.
research Enzyme-Linked Immunosorbent Assays for Doping Control of 5α-Reductase Inhibitors Finasteride and Dutasteride
New tests detect finasteride and dutasteride in urine quickly and easily.
research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders
S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.
research Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases
Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.
research In Vitro Main Pathways of Steroid Action in Cultured Hair Follicle Cells: Vascular Approach
Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.
research The Control of Hair Growth: An Overview
Hair growth is influenced by interactions between skin layers, growth factors, and hormones, but the exact mechanisms are not fully understood.
research A Connection Between the Mitochondrial Permeability Transition Pore, Autophagy, and Cerebral Amyloidogenesis
Dutasteride may help reduce brain plaque linked to Alzheimer's by affecting cell energy structures and waste removal.
research Preparation of Finasteride via Oxidative Elimination of 2-Iododihydrofinasteride Using Peroxydisulfates as Oxidizing Agents
Using K2S2O8 as an oxidizing agent in a specific condition, we can make Finasteride with 96.3% yield and 99.6% purity. This method is also good for other compounds and is environmentally friendly.
research Reaction of Finasteride Intermediate with Benzeneseleninic Anhydride: An In-Depth Study
Impure benzeneseleninic anhydride samples cause lower finasteride intermediate yields.
research Androgenetic Alopecia: In Vivo Models
Stump-tailed macaque best for researching hair loss causes and treatments.
research Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition
Finasteride effectively blocks rat enzymes, but with varying methods and strength.
research Regulatory Roles of Androgens in Cutaneous Wound Healing
Testosterone may slow down wound healing and increase inflammation.
research Status of Medical Treatment for Androgenetic Alopecia
Minoxidil effectively promotes hair regrowth in younger patients with small balding areas.
![Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase](/images/research/d19df8a7-8de6-4430-8a0d-4ffa1f502985/small/15608.jpg)
research Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase
New compounds were made that effectively block a specific enzyme related to androgen conditions.
research Recent Advances in Drug Design and Drug Discovery for Androgen-Dependent Diseases
New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.
research C19 and C21 5β/5α Metabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency
Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.
research Finasteride, a Type 2 5α-Reductase Inhibitor, in the Treatment of Men with Androgenetic Alopecia
Finasteride effectively treats male hair loss, improving growth and density.