research Editorial: Hair Follicle Stem Cell Regeneration in Aging
Aging causes hair loss and graying due to stem cell decline and changes in cell behavior and communication.
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research In Vitro Hair Follicle Growth Model for Drug Testing
Researchers developed a new method to test hair growth drugs and found that adult cells are best for hair growth, but the method needs improvement as it didn't create mature hair follicles.
research Subcutaneous Chest Abscess Caused by Candida Albicans Infection Following Laparoscopic Cholecystectomy in an Immunocompetent Patient: A Case Report
A healthy woman got a chest abscess from a fungal infection after gallbladder surgery, which was treated but caused temporary hair loss due to the antifungal medication.
research Extremely Low-Frequency Electromagnetic Fields Increase Cytokines in Human Hair Follicles Through Wnt/β-Catenin Signaling
Low-frequency electromagnetic fields may help hair growth by affecting certain growth-related molecules.
research Hypoxia Treatment of Adipose Mesenchymal Stem Cells Promotes the Growth of Dermal Papilla Cells via HIF-1α and ERK1/2 Signaling Pathways
Treating fat stem cells with low oxygen boosts hair growth cell growth through specific signaling pathways.
research The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring
PBMCsec can help reduce and improve thick skin scars.
research Deep Hair Phenomics: Implications in Endocrinology, Development, and Aging
A new tool can analyze hair to detect changes due to hormones, genetics, and aging.
research Non-Scarring Alopecia in Females: A Comprehensive Review
Non-scarring alopecia in females affects emotional well-being and requires accurate diagnosis and personalized treatment.
research Coexistence of Malassezia Species and Microsporum Canis in the Lesions of an Adult with Tinea Capitis
An adult woman with scalp infection recovered after antifungal treatment, with no return of symptoms.
research Chemical Constituents of Halophyte Suaeda Glauca and Their Therapeutic Potential for Hair Loss
Suaeda glauca and its compounds could be new treatments for hair loss.
research Modeling of Solar UV-Induced Photodamage on the Hair Follicles in Human Skin Organoids
Sunlight exposure damages hair follicles, but certain stem cell-derived particles can reduce this damage and help with hair regeneration.
research Bioengineered Skin Organoids: From Development to Applications
Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.
research Regulatory Effects of FGF9 on Dermal Papilla Cell Proliferation in Small-Tailed Han Sheep
FGF9 helps hair follicles grow in small-tailed Han sheep by affecting cell growth and certain signaling pathways.
research Scalable and High-Throughput Production of an Injectable Platelet-Rich Plasma (PRP)/Cell-Laden Microcarrier/Hydrogel Composite System for Hair Follicle Tissue Engineering
The developed system could effectively treat hair loss and promote hair growth.
research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis
Hair follicle stem cells can form both hair follicles and skin.
research Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
Low oxygen areas help maintain and protect blood stem cells by using a simple sugar breakdown process for energy and managing their activity levels.
research Fibroblasts: Origins, Definitions, and Functions in Health and Disease
Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.
research c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny
The study explored the effects of c-Myc activation in transgenic mouse epidermis, finding that it led to increased proliferation and differentiation of keratinocytes, particularly towards sebaceous gland lineage, at the expense of hair follicle differentiation. This activation resulted in epidermal thickening, abnormal hair follicles, and increased sebaceous gland size, while maintaining normal terminal differentiation of interfollicular keratinocytes. Transient c-Myc activation was as effective as sustained activation, with effects persisting after treatment cessation. The research highlighted c-Myc's role in promoting sebocyte differentiation and its potential implications for understanding skin disorders and carcinogenesis, suggesting a link between stem cell behavior and neoplastic processes.
research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation
TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.
research Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization
Mitochondrial Complex I reduces inflammation and increases bone breakdown by affecting certain immune cells.
research A Mouse Model for the Basal Transcription and DNA Repair Syndrome Trichothiodystrophy
Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.
research Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis
Mice without the vitamin D receptor are more prone to UV-induced skin tumors.
research Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties
Wounded skin cells can revert to stem cells and help heal.
research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene
Mutations in the Vitamin D receptor gene can cause hair loss similar to mutations in the Hairless gene.
research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome
Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.
research Integument Pattern Formation Involves Genetic and Epigenetic Controls: Feather Arrays Simulated by Digital Hormone Models
Feather patterns form through genetic and epigenetic controls, with cells self-organizing into periodic patterns.
research The Auxin-Regulated CrRLK1L Kinase ERULUS Controls Cell Wall Composition During Root Hair Tip Growth
ERULUS controls root hair growth by regulating cell wall composition and pectin activity.
research Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress
Syndecan-1 is essential for maintaining skin fat and preventing cold stress.
research Dynamic Regulation of Retinoic Acid-Binding Proteins in Developing, Adult, and Neoplastic Skin Reveals Roles for β-Catenin and Notch Signaling
Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.
research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes
Hairless protein can block vitamin D activation in skin cells.