November 2025 in “Frontiers in Pharmacology” In this study, XZYFD, a Traditional Chinese Medicine formulation, was found to improve androgenetic alopecia in a testosterone-induced mouse model by promoting hair regrowth, restoring follicular morphology, and modulating androgen metabolism, MAPK signaling, and lipid metabolism pathways, suggesting potential benefits for patients with metabolic dysfunction.
November 2025 in “Natural Product Communications” This review compiles evidence indicating that rosemary essential oil may enhance cognitive function, sleep quality, mood, and pain management in aromatherapy; however, it also notes potential allergic reactions, emphasizing caution in its use.
April 2025 in “Cosmetics” In this study, synthesized composite nanocarriers containing ribose and peptides demonstrated enhanced transdermal delivery, improved uptake by skin cells, promoted cell proliferation, enhanced antioxidant enzyme activities, and increased autophagy, suggesting a potential for more effective skin anti-aging treatments.
March 2025 in “Tissue and Cell” In this study, cryopreserved fibroblast cell sheets cultured on a new substrate showed significantly enhanced healing of cutaneous ulcers in diabetic and immunodeficient mice, suggesting potential effectiveness for refractory skin wounds.
September 2024 in “Frontiers in Genetics” In this study, researchers found a significant association between the rs13405699 SNP at 2q31.1 and male pattern baldness among Han Chinese men, suggesting genetic influence on this condition in this population.
June 2024 in “International journal of nanomedicine” This study highlights that current research efforts to deliver anti-acne drugs to hair follicles have primarily targeted healthy follicles, overlooking the distinct characteristics of pathologically clogged follicles in acne vulgaris.
November 2023 in “Biomolecules” In this study involving genetically modified rats, researchers observed that specific mutations in the vitamin D receptor affect calcium levels and bone formation, emphasizing the receptor's role in maintaining healthy bone density and its importance in regulating hair cycle and skin health.
October 2023 in “Current Issues in Molecular Biology” In this study, researchers observed that the YH complex, made from Astragalus membranaceus and Cinnamomum cassia, promoted hair regrowth and increased hair shaft thickness in mice, potentially through increased growth factors and Wnt/β-catenin signaling, suggesting its use for treating various forms of hair loss.
September 2023 in “Medicine” This study found increased infiltration of specific immune cells, such as γδ T cells and CD8+ T cells, in the bald scalp of male androgenetic alopecia patients, and identified four key immune-related genes potentially involved in hair loss development through interferon-γ signaling pathways.
July 2023 in “Bioengineering & translational medicine” This study explored a cell-free therapy with mesenchymal stem cell paracrine proteins and PEG hydrogels for deep burn treatment and found that the combination significantly enhanced wound healing, reduced scar formation, and promoted skin appendage regeneration in a rabbit model.
July 2023 in “Journal of medical and health studies” This case study reported on a 3-year-old child with vitamin D-dependent rickets type II treated in the Gaza Strip, whose condition deteriorated despite vitamin D and calcium treatments, leading to recurrent chest infections, respiratory failure, and eventual death.
July 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that back skin mesenchyme from mouse embryos can induce hair follicle formation even before dermal condensate formation, but R-spondin-1 alone or with a Bmp receptor inhibitor was not sufficient for hair follicle induction.
March 2023 in “The Scientific Issues of Ternopil Volodymyr Hnatiuk National Pedagogical University Series pedagogy” In this study, new formulations of 2% minoxidil cream and a minoxidil shampoo with plant antioxidants showed significant hair growth-stimulating and follicle-protective effects in an experimental alopecia model.
March 2021 in “Research Square (Research Square)” This study analyzed the structure and dynamics of ketoconazole, revealing how its molecular characteristics, such as spin-lattice relaxation time and chemical shift anisotropy, are influenced by π-π stacking interactions and different carbon site environments.
May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that hair-type tissues in hedgehogs show higher enrichment of immune-related genes compared to spine-type tissues, suggesting that spines evolved to protect against injuries and infections.
November 2018 in “Springer eBooks” The document concludes that specialized hair transplant techniques can be effective, with varying success rates depending on the donor area and patient factors.
January 2020 in “International Journal of Applied Biology and P” This study found that finasteride treatment for androgenic alopecia significantly increased certain plasma polyamine levels over three years, but did not alter polyamine levels in urine.
4 citations
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December 2022 in “Advanced science” This study found that fatty acid desaturation regulated by SCD1 is crucial for hair growth by maintaining hair follicle stem cell niches, with its absence causing abnormal hair growth in mice.
1 citations
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January 2018 in “Journal of Cosmetic and Laser Therapy” The editorial introduces various topics on laser and cosmetic treatments in a medical journal.
225 citations
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April 2018 in “Journal of Investigative Dermatology” Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.
212 citations
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May 2012 in “Genes & Development” This study identified a set of wound-induced genes in planarians that play a role in regeneration initiation, with some genes specifically activating within regenerative cells called neoblasts.
195 citations
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June 2005 in “American Journal of Human Genetics” Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.
184 citations
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December 2018 in “Nature Communications” This study demonstrated that enhancing human skin constructs with hair follicles through engineered cell organization and vascularization improved hair growth in immunodeficient mice, suggesting potential advances for treating alopecia and chronic wounds.
169 citations
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January 2020 in “Burns & Trauma” In this study, autologous platelet-rich plasma improved skin wound healing in mice, associated with reduced inflammation and enhanced angiogenesis and re-epithelialization, but the underlying regulatory mechanism requires further investigation.
163 citations
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April 2019 in “Nature Communications” This study found that mechanical skin stretching can stimulate hair stem cell proliferation and hair regeneration by activating a complex pathway involving WNT, BMP-2, and M2 macrophages.
157 citations
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October 2003 in “Development” This study found that different stabilizing mutations in Aux/IAA proteins affect root hair development in Arabidopsis by disrupting the auxin response and suggest a model where the relative abundance of these proteins determines root hair initiation.
138 citations
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July 2015 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses how Western diet may contribute to acne vulgaris through insulin signaling and metabolomic changes, promoting a dietary approach for management, but reports no new experimental results.
134 citations
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January 2010 in “Biomedical research” This study found that subcutaneous administration of conditioned medium from adipose-derived stem cells promoted hair growth in mice, and hypoxia enhanced this effect by altering growth factor secretion.
130 citations
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April 2001 in “Journal of Investigative Dermatology” This study reports the first keratin gene mutation affecting the tail domain, leading to a unique cytoskeletal abnormality and severe epidermal hyperkeratosis, highlighting the tail domain's critical role in keratin organization.
123 citations
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May 2009 in “Journal of Neuroscience” In this study, researchers found that in late pregnancy, the neuroactive progesterone metabolite allopregnanolone inhibits HPA axis responses to immune challenges via an opioid-mediated mechanism.