Comparative Studies of Specific Activity of Soft Dosage Forms of Minoxidil for Trichological Practice

    В. В. Гладишев, О. Б. Харапонова, А. Д. Дюдюн, І. О. Пухальська, С. А. Гладишева, А. В. Курінний, Г. П. Лисянська
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    Studysummary In this study, new formulations of 2% minoxidil cream and a minoxidil shampoo with plant antioxidants showed significant hair growth-stimulating and follicle-protective effects in an experimental alopecia model.
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    The study conducted by Zaporizhzhia State Medical University evaluated two new topical minoxidil formulations—a 2% cream and a 1% gel-based shampoo—designed to treat androgenic alopecia. The research demonstrated that both formulations exhibited significant hair growth-stimulating and follicle-protective activities in experimental alopecia models. The 2% minoxidil cream showed a comparable growth-stimulating effect to the reference spray "Pilfood Bosnalek," while the "Trichlomine" shampoo outperformed the reference "Dove" shampoo in stimulating hair growth. The shampoo's enhanced effect was attributed to its plant-antioxidant complex, which potentiated minoxidil's action. However, neither the cream nor the reference products significantly impacted dermal energy metabolism indicators.
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