Study of the Structural-Mechanical Properties of Cream with Minoxidil

January 2016

I. V. Gnitko, A. P. Lisyanskaya, S. А. Gladisheva

minoxidil androgenous alopecia rheological characteristics rotary viscosimeter thixotropic properties dynamic flow factors active substance excipients Rogaine hair growth hair recovery ointment consistency skin distribution formulation stability

TLDR The 2% minoxidil cream is stable, spreads well on the skin, and helps with hair growth.

The study conducted by Zaporizhzhia State Medical University evaluated the rheological characteristics of a 2% minoxidil cream for external use, aimed at stabilizing hair growth and recovering hair in individuals with androgenous alopecia. Using a rotary viscosimeter, the cream was found to have optimal ointment consistency and exceptional thixotropic properties, indicating its stability under mechanical stress and during long-term storage. The dynamic flow factors confirmed the cream's adequate distribution on the skin. Additionally, the minimal interaction between the active substance and excipients was noted, suggesting a stable formulation.

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research Thermogravimetric Investigations of Cream with Minoxidil

September 2016 in “Aktualʹnì pitannâ farmacevtičnoï ì medičnoï nauki ta praktiki”

The minoxidil cream-mask is stable and effective for hair growth when prepared at 60-80ºC.