Integrating Stem Cell Biology and Organoid Technology for Skin Regenerative Therapies

    January 2025 in “ Health engineering.
    Ke Zheng, Qingyang Yang, Yaojiong Wu
    TLDR Combining stem cells and organoids could improve skin regeneration treatments.
    The document explores the integration of stem cell biology and organoid technology for skin regenerative therapies, emphasizing their potential in addressing skin aging and hair loss. Skin stem cells are vital for skin maintenance and regeneration, but aging impairs their function, leading to issues like hair loss. Organoid models provide insights into skin aging mechanisms and regenerative therapies. The document highlights the role of inflammaging, chronic inflammation, and changes in the epithelial microenvironment in skin aging. Skin organoids, derived from primary cells or iPSCs, are promising for studying aging and testing therapies, including anti-aging interventions targeting cellular senescence, inflammation, and ECM improvement. Compounds like fisetin, senolytics, and ECM-targeting agents show potential in enhancing skin elasticity and reducing wrinkles. Stem cell-based therapies, particularly using adipose-derived and mesenchymal stem cells, show promise in promoting skin regeneration and reducing age-related changes. However, challenges in standardizing protocols and ensuring safety and efficacy remain, necessitating further research.
    Discuss this study in the Community →

    Research cited in this study

    33 / 33 results