Influence of Nanocrystal Size on the In Vivo Absorption Kinetics of Caffeine After Topical Application

July 2021 in “ European journal of pharmaceutics and biopharmaceutics ”

P. Breuckmann, Martina C. Meinke, Th. Jaenicke, Jean Krutmann, У. Х. Расулев, Cornelia M. Keck, Rainer H. Müller, Anna Lena Klein, Jürgen Lademann, Alexa Patzelt

nanocrystal caffeine topical application hair follicles nanoparticles transfollicular delivery nanocarriers absorption kinetics dermal drug delivery

Studysummary This study reported that larger caffeine nanocrystals, at 694 nm, increased caffeine bioavailability via transfollicular penetration compared to smaller nanocrystals, especially in long-term serum concentration measurements.

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