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    Integrated Multiomics Analysis Reveals the Molecular Features and Crucial Regulators of Hair Follicles in Yak (Bos Grunniens)

    January 2026 in “ Communications Biology ”
    Ke Zhang, Luyao Zhang, Xiang Qin … Qi-en Yang
    Studysummary This study constructed a single-cell atlas of hair follicle cells from yaks and taurine cattle, revealing that differences in WNT signaling within dermal papilla cells may be key to the yak's adaptation to cold environments on the Qinghai-Tibet Plateau.
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    Research cited in this study 26

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    2. Crosstalk Between Endothelial Cells and Dermal Papilla Entails Hair Regeneration and Angiogenesis During Aging Journal of Advanced Research · 2024
    3. Autophagy Induces Hair Follicle Stem Cell Activation and Hair Follicle Regeneration by Regulating Glycolysis 2024
    4. The Roles of WNT Signaling Pathways in Skin Development and Mechanical-Stretch-Induced Skin Regeneration Biomolecules · 2023
    5. Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Identify Gene-Regulatory Programs and Critical Cell Types for Hair and Skin Diseases Nature Genetics · 2023
    6. Comparative Analysis of mRNA and miRNA Expression Between Dermal Papilla Cells and Hair Matrix Cells of Hair Follicles in Yak Cells · 2022
    7. Exosomal miRNA-181a-5p from Hair Follicle Dermal Papilla Cells Promotes Hair Follicle Growth and Development via the Wnt/β-Catenin Signaling Pathway International journal of biological macromolecules · 2022
    8. Myristoleic Acid Promotes Anagen Signaling by Autophagy Through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells Biomolecules & therapeutics · 2021
    9. Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation Journal of Investigative Dermatology · 2021
    10. Expression and Localization of Sox10 During Hair Follicle Morphogenesis and Induced Hair Cycle International Journal of Medical Sciences · 2021
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    12. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
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    18. Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro British Journal of Dermatology · 2014
    19. Identification of MicroRNAs in Wool Follicles During Anagen, Catagen, and Telogen Phases in Tibetan Sheep PLoS ONE · 2013
    20. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    21. Committing to a Hairy Fate: Epigenetic Regulation of Hair Follicle Stem Cells Cell stem cell · 2011
    22. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    23. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    24. Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate Development · 2008
    25. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    26. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004