Insights from Tandem Mass Tag Proteomic Analysis on Protein Network Modification in Control of Yak Hair Follicle Cycle

February 2025 in “ International Journal of Molecular Sciences ”

Shijie Li, Yan Cui, Sijiu Yu, Junfeng He, Rui Ma, Bo Liao, Pengfei Zhao, Pengqiang Wei, Robert Niayale

Tandem Mass Tag proteomics hair follicle growth cycle Sfrp1 Ppard WNT pathway VEGF pathway JAK-STAT pathway PPAR pathway complement system estrogen pathway Protein-Protein Interaction analysis lipid metabolism proteins

TLDR Key proteins and pathways regulate yak hair growth, with lipid metabolism aiding adaptation to high altitudes.

The study used Tandem Mass Tag (TMT) proteomic analysis to explore protein network modifications in yak hair follicles, identifying 3176 quantifiable proteins and 1142 differentially expressed proteins (DEPs) across five stages of the hair cycle. Key proteins like Sfrp1 and Ppard were found to regulate the hair cycle, with pathways such as WNT, VEGF, JAK-STAT, and PPAR being crucial for hair growth and degeneration. The research, conducted on five healthy male yaks, emphasizes the role of lipid metabolism in hair follicle cycling and adaptation to high-altitude environments, offering insights into molecular mechanisms and potential economic benefits for yak livestock.

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