Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

    May 2020 in “ Cells ”
    Hyun‐A Oh, Jae-Man Kwak, Beom Joon Kim, Hye Jin Jin, Won Seok Park, Soo Jin Choi, Wonil Oh, Soyoun Um
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    TLDR Substance from human umbilical cord blood cells promotes hair growth.
    The document presents a study on the effects of conditioned medium (CM) from human umbilical cord blood-derived mesenchymal stromal cells (hUCB-MSCs) on hair growth, specifically targeting androgenetic alopecia. The researchers developed an optimized CM (P-CM) by treating hUCB-MSCs with TGF-ß1 and LiCl, which led to a significant increase in the viability of dermal papilla cells (DPCs) and the secretion of vascular endothelial growth factor (VEGF) through macrophage migration inhibitory factor (MIF). Clinical trials with 30 participants aged 20 to 60 years showed that topical application of 5% P-CM over 16 weeks resulted in increased hair density and thickness. A separate study with 52 patients (43 completed) confirmed increased hair density after 24 weeks of treatment. The findings suggest that MIF in P-CM stimulates hair growth via the VEGF-related ß-catenin and p-GSK-3ß [SER9] signaling pathway, indicating that P-CM could be a novel treatment for androgenetic alopecia.
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