Medicinal and edible plant Allium macrostemon Bunge for the treatment of testosterone-induced androgenetic alopecia in mice

    October 2023 in “Journal of Ethnopharmacology
    TLDR The wild garlic plant, Allium macrostemon Bunge, can promote hair growth and could potentially be used to treat hair loss.
    The study investigated the effects of Allium macrostemon Bunge (AMB), a wild garlic plant, on androgenetic alopecia (AGA) in mice. The results showed that AMB promoted the proliferation and migration of human dermal papilla cells (HDPCs), and inhibited their apoptosis. AMB also activated the Wnt/β-catenin signaling pathway, which is involved in hair follicle formation and growth factor secretion. When this pathway was inhibited, the beneficial effects of AMB on HDPCs were abolished, suggesting that the Wnt/β-catenin signaling pathway is necessary for AMB's effects. In a testosterone-induced AGA mouse model, topical application of AMB promoted hair regeneration, with a higher Hair Growth Index, longer hair length, and greater hair weight compared to the control group. These findings suggest that AMB could be a potential treatment for AGA.
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