Medicinal and Edible Plant Allium Macrostemon Bunge for the Treatment of Testosterone-Induced Androgenetic Alopecia in Mice

    May 2023 in “ Journal of Ethnopharmacology
    Ruiyang Gao, Zhilun Yu, Cheng Lv, Xiaolong Geng, Yijing Ren, Junyu Ren, Hao Wang, Fangbin Ai, Beibei Zhang, Bei Yue, Zhengtao Wang, Wei Dou
    Image of study
    TLDR The wild garlic plant, Allium macrostemon Bunge, can promote hair growth and could potentially be used to treat hair loss.
    The study investigated the effects of Allium macrostemon Bunge (AMB), a wild garlic plant, on androgenetic alopecia (AGA) in mice. The results showed that AMB promoted the proliferation and migration of human dermal papilla cells (HDPCs), and inhibited their apoptosis. AMB also activated the Wnt/β-catenin signaling pathway, which is involved in hair follicle formation and growth factor secretion. When this pathway was inhibited, the beneficial effects of AMB on HDPCs were abolished, suggesting that the Wnt/β-catenin signaling pathway is necessary for AMB's effects. In a testosterone-induced AGA mouse model, topical application of AMB promoted hair regeneration, with a higher Hair Growth Index, longer hair length, and greater hair weight compared to the control group. These findings suggest that AMB could be a potential treatment for AGA.
    Discuss this study in the Community →

    Research cited in this study

    26 / 26 results

    Related Community Posts Join

    5 / 5 results

      community Topical finasteride carrier vehicle

      in Finasteride/Dutasteride  1 upvotes 5 days ago
      The user is using a topical solution containing 1% finasteride and 5% minoxidil for hair loss, with water, glycerin, and PEG-40 hydrogenated castor oil as carrier agents. They are questioning if these ingredients are effective carriers after using the solution for three months.

      community Question regarding Topical finasteride solution

      in Finasteride/Dutasteride  3 upvotes 1 month ago
      A user is using a topical spray containing Finasteride 1% and Minoxidil 5% along with other ingredients like glycerin and aqua, questioning if these are effective carrier agents. They apply it once daily and use a separate 5% Minoxidil solution at night.

      community Does onion juice actually stop hair fall, or is it just hype?

      in Treatment 1 week ago
      Onion juice may temporarily improve hair health by boosting blood circulation and providing antibacterial benefits, but it is ineffective against genetic or hormonal hair loss. Proven treatments like minoxidil and finasteride are recommended for more reliable results.

    Similar Research

    5 / 247 results