SIRT7 Activates Quiescent Hair Follicle Stem Cells to Ensure Hair Growth in Mice

    July 2020 in “ EMBO journal ”
    Guo Li, Xiaolong Tang, Shuping Zhang … Baohua Liu
    Studysummary In this study, researchers found that SIRT7 activates quiescent hair follicle stem cells to promote hair growth in mice by triggering the telogen-to-anagen cycle transition, with potential implications for age-related hair loss.
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    Research cited in this study 20

    1. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    2. Glutamate Transporter SLC1A3 Mediates Inter-Niche Stem Cell Activation During Skin Growth EMBO journal · 2018
    3. Dermal-Epidermal Cross-Talk: Differential Interactions With Microvascular Endothelial Cells Journal of Cellular Physiology · 2016
    4. Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells Science · 2016
    5. Aging, Alopecia, and Stem Cells Science · 2016
    6. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    7. Calcineurin/NFATc1 Signaling Links Skin Stem Cell Quiescence to Hormonal Signaling During Pregnancy and Lactation Genes & Development · 2014
    8. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    9. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    10. Nuclear Factor I-C Regulates TGF-β-dependent Hair Follicle Cycling Journal of Biological Chemistry · 2010
    11. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    12. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    13. Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion Stem Cells · 2006
    14. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    15. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    16. Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes American Journal of Physiology-cell Physiology · 2003
    17. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    18. Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin The FASEB Journal · 2001
    19. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    20. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999

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