Dermal-Epidermal Cross-Talk: Differential Interactions With Microvascular Endothelial Cells

October 2016 in “ Journal of Cellular Physiology ”

Eleonora Bassino, Edoardo Vallariello, F Gasparri, Luca Munaron

dermal fibroblasts NHDF microvascular endothelial cells HMVEC keratinocytes follicle fibroblasts conditioned media pro-inflammatory markers skin fibroblasts endothelial cells hair follicle cells inflammatory markers

TLDR Human dermal fibroblasts help microvascular endothelial cells grow, but not vice versa.

The study demonstrated that human dermal fibroblasts (NHDF) enhanced the viability and proliferation of microvascular endothelial cells (HMVEC), whereas HMVEC did not stimulate NHDF proliferation. Using triculture setups, the researchers found that conditioned media from cocultures (HMVEC/NHDF or HMVEC/follicle fibroblasts) differentially influenced the growth and proliferation of keratinocytes and modified the expression of metabolic and pro-inflammatory markers. This approach provided valuable insights into dermal-epithelial and endothelial interactions, suggesting that tricultures could complement ex vivo and in vivo methods through high-throughput and standardized protocols under controlled conditions.

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Dermal-Epidermal Cross-Talk: Differential Interactions With Microvascular Endothelial Cells

Research cited in this study

research Paracrine Crosstalk Between Human Hair Follicle Dermal Papilla Cells and Microvascular Endothelial Cells

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research IL-1 Alpha Inhibits Human Hair Follicle Growth And Hair Fiber Production In Whole-Organ Cultures

research The Secret Life of the Hair Follicle

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