Hispidulin Ameliorates Androgenetic Alopecia by Inhibiting Dermal Papilla Cell Ferroptosis via TRPML1 Channel Activation

    July 2026 in “ Free Radical Biology and Medicine ”
    Xiaofan Jin, Hongyan Zhang, Yetan Shi … Xiuzu Song
    Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

    We don't know much about this study yet.

    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 21

    1. Sinapic Acid and Glabridin Synergistically Mitigate Androgenetic Alopecia by Modulating Ferroptosis Through Stabilization of Beta-Catenin Against Ubiquitin-Dependent Degradation PubMed · 2025
    2. Role of UVA-Driven Cellular Senescence via mTOR Activation in Dihydrotestosterone-Induced Hair Loss in Androgenetic Alopecia Mouse Model Journal of Photochemistry and Photobiology B Biology · 2025
    3. S100A8 Induces Cyclophosphamide-Induced Alopecia via NCF2/NOX2-Mediated Ferroptosis Free Radical Biology and Medicine · 2025
    4. Anti-Androgenetic Effect of Diphlorethohydroxycarmalol on Testosterone-Induced Hair Loss by Inhibiting 5α-Reductase and Promoting Wnt/β-Catenin Signaling Pathway in Human Dermal Papilla Cells Toxicology in Vitro · 2025
    5. Ellagic Acid Inhibits Dihydrotestosterone-Induced Ferroptosis and Promotes Hair Regeneration by Activating the Wnt/Beta-Catenin Signaling Pathway Journal of ethnopharmacology · 2024
    6. Emerging and Traditional 5-Alpha Reductase Inhibitors and Androgen Receptor Antagonists for Male Androgenetic Alopecia Expert opinion on emerging drugs · 2024
    7. Transient Stimulation of TRPMLs Enhances the Functionality of HDPCs and Facilitates Hair Growth in Mice Cellular signalling · 2024
    8. Androgenetic Alopecia: An Update JAAD International · 2023
    9. Schizochytrium Sp. Extracted Lipids Prevent Alopecia by Enhancing Antioxidation and Inhibiting Ferroptosis of Dermal Papilla Cells Antioxidants · 2023
    10. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    11. Hyperandrogenism and Insulin Resistance Modulate Gravid Uterine and Placental Ferroptosis in PCOS-Like Rats Journal of Endocrinology · 2020
    12. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    13. Testosterone Alters Iron Metabolism and Stimulates Red Blood Cell Production Independently of Dihydrotestosterone American Journal of Physiology-Endocrinology and Metabolism · 2014
    14. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    15. A Mouse Model of Androgenetic Alopecia Endocrinology · 2010
    16. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006
    17. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    18. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    19. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    20. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999
    21. Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo and In Vitro Journal of Investigative Dermatology · 1998