Hair Regeneration in Alopecia Using Adipose-Derived Mesenchymal Stem Cells Secretome: A Systematic Review of Experimental and Clinical Evidence

    August 2026 in “ Tissue and Cell ”
    Wahyu Widowati, Lika Iriana Risda Putri, Fenska Seipalla … Elnaz Zand
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    Research cited in this study 19

    1. Insulin-Like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential Current Issues in Molecular Biology · 2025
    2. Exosomes And Hair Regeneration: A Systematic Review Of Clinical Evidence Across Alopecia Types And Exosome Sources Clinical Cosmetic and Investigational Dermatology · 2025
    3. Mechanisms and Clinical Progress of Adipose-Derived Stem Cells and Their Derivatives in the Treatment of Hair Loss Stem Cell Research & Therapy · 2025
    4. Hair Growth Stimulated by Allogenic Adipose-Derived Stem Cells Supplemented with ATP in a Mouse Model of Dihydrotestosterone-Induced Androgenetic Alopecia Stem Cell Research & Therapy · 2025
    5. Mesenchymal Stem Cell Exosomes Enhance the Development of Hair Follicle to Ameliorate Androgenetic Alopecia World Journal of Stem Cells · 2025
    6. Therapeutic Potential of Adipose-Derived Stem Cells and Their Secretome in Reversible Alopecias: A Systematic Review International Journal of Trichology · 2023
    7. Combination of Adipose-Derived Stem Cell Conditioned Media and Minoxidil for Hair Regrowth in Male Androgenetic Alopecia: A Randomized, Double-Blind Clinical Trial Stem Cell Research & Therapy · 2023
    8. Hypoxia Treatment of Adipose Mesenchymal Stem Cells Promotes the Growth of Dermal Papilla Cells via HIF-1α and ERK1/2 Signaling Pathways International Journal of Molecular Sciences · 2023
    9. Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway International Journal of Molecular Sciences · 2023
    10. Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature Regenerative Therapy · 2022
    11. Stem Cell Secretome as a Mechanism for Restoring Hair Loss Due to Stress, Particularly Alopecia Areata: Narrative Review Journal of Biomedical Science · 2022
    12. 3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoting Compounds: Examples of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid (TCQA) Cells · 2022
    13. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    14. Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-Conditioning Frontiers in Immunology · 2018
    15. Cellular Therapy with Human Autologous Adipose-Derived Adult Cells of Stromal Vascular Fraction for Alopecia Areata Stem Cell Research & Therapy · 2018
    16. Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study International Journal of Dermatology · 2015
    17. Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion Biomedical research · 2010
    18. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    19. The Biology of Hair Follicles The New England Journal of Medicine · 1999