Fibroblast Heterogeneity in Healthy and Wounded Skin

This review discusses the development, lineages, functions, and roles of fibroblasts in fibrosis across four organs, highlighting their capabilities in tissue repair and contributions to fibrotic disorders when aberrantly activated, but it reports no new experimental findings.

This study found that Ng2+ perivascular cells in mouse skin are a diverse lineage-restricted population primarily recruited from papillary or reticular fibroblast lineages during wound healing, maintaining heterogeneity in both wounded and non-wounded skin.

In this study, researchers found that extrafollicular progenitors marked by Hic1 are the main contributors to reparative fibroblasts in wound repair, with potential to modulate healing outcomes through genetic and pharmacological interventions.

This review explores the diverse roles and heterogeneity of fibroblasts across different organs, highlighting their potential involvement in both normal tissue functioning and fibrotic diseases, but reports no new experimental results.

This study found that mature dermal adipocytes have high plasticity, undergoing dedifferentiation and redifferentiation, which plays a significant role in hair cycling and wound healing.

In this study, researchers found that wound healing in mouse skin recruits diverse fibroblasts, including myeloid-derived cells, which contribute to regenerating adipocytes.

This study found that activating the Sonic hedgehog pathway in scarring wounds can remodel the dermis to promote hair follicle regeneration, highlighting a potential new approach to enhance healing.

This study identified two cell surface markers, FAP and CD90, that distinguish between papillary and reticular fibroblasts in human skin, suggesting distinct functions and distribution in dermal layers.

This study found that in murine dermis, fibroblast state switching between proliferation and ECM deposition plays a crucial role in tissue architecture and wound healing.

This review explores recent insights into the diverse cell populations involved in skin development, homeostasis, wound healing, and cancer progression but reports no new results.

Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.

This study identified at least four distinct fibroblast populations in adult human skin, each with unique functional properties, suggesting potential therapeutic applications for wound healing and fibrosis-related diseases.

In this study, researchers identified gremilin-2 as a highly specific gene to the dermal sheath cup, suggesting it plays a key role in maintaining its properties.

This study found that Blimp1 plays a key role in promoting hair follicle morphogenesis and growth by mediating inductive signaling pathways in dermal papilla cells.

This study found that hair follicles in mice and humans can convert wound-related myofibroblasts into adipocytes, suggesting a potential pathway to reduce scar formation by activating BMP signaling.

The authors concluded that the dermal response to epidermal Wnt/β-catenin signaling depends on distinct fibroblast lineages, with each responding to different paracrine signals such as Hedgehog and TGF-β.

This study suggests that the postnatal loss of hair follicle formation in wounds may be due to elevated Wnt/β-catenin activation in the dermis, affecting fibroblast function in mice.

In this study using a mouse model, Prom1+ dermal papilla cells were found to regulate the size of the papilla via β-catenin communication but did not aid in dermal repair.

This review explores the evolution and development of skin-associated adipose tissue and proposes new nomenclature for the cells and adipose tissue underlying the reticular dermis, without reporting clinical results.

This research abstract provides no results, focusing on the equal contributions of the authors in the field of molecular, cellular, and developmental biology from Yale University.

This study found that skin fibroblasts in mice arise from two distinct lineages which contribute differently to dermal structure and repair, impacting hair follicle formation during wound healing.

This study found that altering cell culture conditions to form three-dimensional papilla spheroids can restore the ability of human dermal papilla cells to induce hair growth in adult skin.

This study found that fibroblast growth factor 9, initially secreted by γδ T cells, plays a key role in modulating hair follicle regeneration in mice after skin wounds.

This study reports the first instance of skin autotomy in mammals, specifically in African spiny mice, and suggests they may possess a greater regenerative capacity than previously understood, possibly offering insights for regenerative medicine.

This study found that distinct low-threshold mechanoreceptors innervate different hair follicle types in mice, suggesting that these follicles serve as unique mechanosensory structures in touch perception.

This study found that adult mouse dermis can be reprogrammed by epidermal cues to resemble neonatal dermis, with changes in fibroblast proliferation and extracellular matrix composition.

This study found that intradermal adipocyte lineage cells in mice are necessary and sufficient to activate follicular stem cells, highlighting their role in regulating skin stem cell activity.

Nephronectin helps attach muscle cells to hair follicles.

This study demonstrates that Sox2-positive dermal papilla cells specify particular hair follicle types by showing heterogeneity in gene expression and pathway activation in these cells.

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

This study suggests that keratin 9 expression in nonpalmoplantar keratinocytes can be induced by signals from palmoplantar fibroblasts, potentially enabling the use of nonpalmoplantar epidermis to treat palmoplantar wounds.

This study found that dermal papilla cells from balding scalp hair follicles have significantly higher levels of androgen receptors than those from non-balding follicles, supporting their in vivo androgen response.