Frontal fibrosing alopecia: An update on the hypothesis of pathogenesis and treatment
June 2019
in “International Journal of Women's Dermatology”
TLDR The document concluded that more research is needed to find the best treatment for Frontal fibrosing alopecia.
In 2019, the document "Frontal fibrosing alopecia: An update on the hypothesis of pathogenesis and treatment" suggested that Frontal fibrosing alopecia (FFA) is likely a lymphocytic cicatricial alopecia, with its pathogenesis potentially related to hormonal factors, genetic predisposition, and environmental triggers. The paper discussed various treatments, including 5-alpha reductase inhibitors, hydroxychloroquine, and intralesional corticosteroids, but noted that no single treatment was universally effective. The study also highlighted the role of T cells, mast cells, and sebaceous glands in the pathogenesis of FFA. It suggested that aberrant innate immune responses could be the initiating event during FFA and discussed the role of the epithelial-to-mesenchymal transition (EMT) in FFA. The document concluded that further clinical trials and hypothesis studies were needed to clarify the most effective approaches for the treatment of FFA.
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