Frontal Fibrosing Alopecia: A Comprehensive Review with Recent Updates

    January 2025 in “ Indian Journal of Dermatology
    Shikha Verma, Anita Marak, Debopriya Paul
    Frontal fibrosing alopecia (FFA) is a primary lymphocytic scarring alopecia mainly affecting postmenopausal women, characterized by hairline recession. Its cause is unknown, but genetic, autoimmune, hormonal, and environmental factors are implicated. A study in New York City estimated its prevalence at 0.015%. FFA is associated with autoimmune diseases and often coexists with androgenetic alopecia. Clinical features include eyebrow and eyelash involvement and symptoms like pruritus. Histopathology shows lichenoid lymphocytic infiltrate and perifollicular fibrosis. Despite various treatments, including oral 5-α reductase inhibitors, managing FFA is challenging, and no definitive therapy exists. Further research is needed to understand its hormonal and genetic influences.
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