Exosomes Versus Platelet-Rich Plasma in Hair Loss Therapy: A Comprehensive Literature Review

January 2026 in “ Journal of Advanced Trends in Medical Research ”

Nouf Bin Rubaian, Sara Mahfoud Alghamdi, M. Alahmadi, Almaha Alhijab, Tala Alshamrani, Hussam T. Hakami, Latifah Almehaideb, Lama Alghamdi, Hisham Alahmadi, Ghaida Bandar Alanazi

exosome therapy platelet-rich plasma PRP mesenchymal stem cells dermal papilla cells androgenetic alopecia chemotherapy-induced alopecia trichorrhexis nodosa alopecia areata follicular regeneration exosomes

TLDR Exosomes and PRP both show promise for hair loss treatment, but more research is needed.

The review compares exosome therapy and platelet-rich plasma (PRP) for hair loss treatment, highlighting exosomes' potential in regenerative dermatology. Exosomes, particularly from mesenchymal stem cells and dermal papilla cells, show promise in enhancing hair density and transitioning hair phases, with a study of 30 male patients with androgenetic alopecia showing increased hair density. Exosomes may also benefit chemotherapy-induced alopecia and trichorrhexis nodosa. PRP, derived from a patient's blood, has a longer clinical history and is effective in treating various alopecia types, including androgenetic alopecia and alopecia areata, by increasing hair density and stimulating follicular regeneration. Both therapies face challenges like standardization and regulatory issues, and further research is needed to confirm long-term efficacy and establish treatment protocols.

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