Dyslipidemia, Hormonal Profiles, and Sleep Characteristics in Men With Androgenetic Alopecia: An Analysis Based on Data From the EPISONO Study

This study provides an overview of androgenetic alopecia in the USA, highlighting social determinants, differences in onset between genders, and how management varies by age and gender.

In this study, lipid metabolism was found to be reduced in scalp tissues of patients with androgenetic alopecia, and lipid supplementation enhanced hair growth-related gene expression in human dermal papilla cells, suggesting a potential role for lipids in promoting hair growth through HIF-1 signaling.

This study found that early-onset male androgenetic alopecia is associated with abnormal lipid metabolism and lower levels of certain serum markers, which may serve as risk factors or protective factors for the condition.

This review examines the hormonal causes of hair loss, noting how androgen excess can lead to follicle miniaturization and linking estrogen deficiency and thyroid dysfunction to common alopecia types. It further discusses hormonal treatments such as finasteride, dutasteride, and spironolactone.

In this study, AGA patients exhibited distinct lipidomic profiles and higher metabolic syndrome prevalence compared to controls, with certain lipids correlated to key AGA-related factors like DHT, PGD2, and TGF-β1.

This study found that androgenetic alopecia in men was significantly associated with dyslipidemia, particularly in more severe cases, suggesting it could be a marker for systemic illness.

This study describes androgenetic alopecia as a common non-scarring hair loss condition primarily influenced by genetic factors and androgen sensitivity, notably impacting psychosocial well-being, especially in females and younger males seeking treatment.

The researchers reported that an oral supplement containing hydrolysed fish-origin collagen, taurine, cysteine, methionine, iron, and selenium significantly improved the effectiveness of anti-hair loss treatments in people with androgenic alopecia or chronic telogen effluvium after 12 weeks, compared to drug treatments alone.

This study found an association between sleep disturbances and androgenetic alopecia in men, with severe AGA linked to shorter sleep duration, poorer sleep quality, and higher STOP-BANG scores.

This meta-analysis found that patients with androgenetic alopecia had a significantly higher prevalence of metabolic syndrome and poorer metabolic profiles compared to controls, especially among females, those with early onset, and individuals of African ethnicity.

This study found that men with early-onset androgenetic alopecia may experience less benefit from rosuvastatin treatment in terms of improving cardiometabolic risk factors compared to men with normal hair growth.

This study found that men with early-onset androgenetic alopecia and certain risk factors may have worse gonadal steroidogenesis and an increased likelihood of developing gonadal dysfunction, suggesting a male equivalent of polycystic ovarian syndrome.

This review discusses the physiopathology of androgenetic alopecia and evaluates various traditional and emerging treatments, reporting no new clinical results but highlighting the need for enhanced treatment strategies.

This review discusses the role of cholesterol homeostasis in hair follicle biology and its potential connections to various hair disorders, but it reports no new findings.

This guideline review by the European Dermatology Forum evaluates current treatments for androgenetic alopecia but reports no new research findings, aiming to assist dermatologists in selecting safe and effective therapies.

This review examines recent advances in understanding the pathophysiology and molecular mechanisms of androgenetic alopecia, highlighting two major genetic risk loci, but does not report new clinical findings.

This meta-analysis found that patients with androgenetic alopecia have significantly abnormal lipid profiles, which could contribute to the link between this condition and cardiovascular diseases.

This study found that apoptosis was more prevalent in hair follicles of women with female pattern hair loss, particularly in miniaturized follicles, and was associated with follicular inflammation.

This study found that males with androgenetic alopecia had a significantly lower 2D:4D digit length ratio in the right hand compared to healthy controls, which may indicate prenatal androgen exposure.

This meta-analysis found that people with alopecia have an increased risk of coronary heart disease and several cardiovascular risk factors compared to those without alopecia.

Hair loss linked to higher heart disease risk in both men and women.

This study found a significant association between androgenetic alopecia and metabolic syndrome, highlighting high-density lipoprotein cholesterol as a particularly important factor.

This paper discusses key mechanisms of androgen metabolism in androgenetic alopecia and reports the effectiveness of treatments like oral finasteride and topical minoxidil, highlighting the limited success rate due to factors like follicular inflammation.