Corticotropin-Releasing Factor Down-Regulates Hair Growth-Related Cytokines in Cultured Human Dermal Papilla Cells
December 2014
in “
Journal of the Society of Cosmetic Scientists of Korea
”
Research cited in this study
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research CRF Receptor Antagonist Astressin-B Reverses and Prevents Alopecia in CRF Over-Expressing Mice
Astressin-B can reverse and prevent hair loss in stressed mice.
research TGF-β2 Is Specifically Expressed in Human Dermal Papilla Cells and Modulates Hair Folliculogenesis
TGF-β2 plays a key role in human hair growth and development.
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All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.
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research Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways
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research The chemotactic effect of a dermal papilla cell-derived factor on outer root sheath cells
research Message of nexin 1, a serine protease inhibitor, is accumulated in the follicular papilla during anagen of the hair cycle
Nexin 1 may help control hair growth.
research Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia.
The study demonstrated that keratinocyte growth factor (KGF or FGF-7) played a significant role in hair follicle growth, development, and differentiation. KGF and its receptor were highly expressed in skin, particularly in developing hair follicles. In experiments with nu/nu athymic nude mice, recombinant KGF (rKGF) induced dose-dependent hair growth and normalized follicular defects. Additionally, in a neonatal rat model of chemotherapy-induced alopecia, rKGF provided a dose-dependent protective effect, reducing alopecia by up to 50%. These findings suggested that KGF was a crucial endogenous factor in hair follicle biology.
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Systemic diseases can cause hair loss, which is often reversible with treatment.
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