Alopecia Areata: An Autoimmune Hair Loss Condition

    January 2016 in “ Springer eBooks
    Abdullah Alkhalifah
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    TLDR Alopecia Areata is an unpredictable autoimmune hair loss condition with limited and variable treatment effectiveness.
    The 2016 document details Alopecia Areata (AA), an autoimmune hair loss condition without a known cure. It affects up to 3.8% of dermatology patients and has a lifetime risk of 1.7%, with 20% of cases occurring in children. The condition can lead to different patterns of hair loss and has an unpredictable course, with 50% of patients seeing spontaneous recovery within a year, but 85% may relapse. Treatment options like topical and intralesional steroids, minoxidil, anthralin, and topical immunotherapy vary in effectiveness, and systemic therapies often come with severe side effects and high relapse rates. New treatments, including JAK inhibitors and low-dose interleukin-2, show promise but need more research. The document recommends addressing the psychological impact of AA, especially in pediatric patients, and suggests different treatment approaches based on age, with topical corticosteroids and minoxidil for those under 12, and a combination of therapies for those 12 and older. Screening for thyroid dysfunction is also advised, particularly for patients with a family history of thyroid disease.
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      community My experience and a discourse on “DUPA”

      in Chat  46 upvotes 2 years ago
      How diffuse unpatterned alopecia (DUPA) is not an invitation to self-diagnose oneself with aggressive AGA and that seeking a specialized dermatologist may help people experiencing hair loss. Treatment options discussed include topical clobetasol propionate, oral minoxidil, and discontinuing finasteride.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 6 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Rare Non responder to Finasteride, Dutasteride, and oral minoxidil

      in Minoxidil  78 upvotes 11 months ago
      A user did not respond to finasteride, dutasteride, and oral minoxidil for hair loss after four years of treatment and is considering scalp micropigmentation (SMP). Other users suggest the hair loss pattern may indicate alopecia areata and recommend seeing a dermatologist.

      community *WOMEN* on Spironolactone - experiences?

       6 upvotes 9 years ago
      Hair loss treatments discussed: Minoxidil, Finasteride, RU58841, and Spironolactone. Woman with androgenetic alopecia and alopecia areata shares experience using Spironolactone.

      community Losing hair everywhere, idk what to do :(

       29 upvotes 6 years ago
      A 22-year-old male has been experiencing widespread hair loss for over four years, including pain and significant shedding. Treatments tried include ketoconazole shampoo, fluocinonide topical solution, biotin, ACV, and dry shampoo, but none have been effective.

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