Assessment of Adipokines, Hormonal Profile, Lipid Profile, and Insulin Resistance in Patients with Androgenetic Alopecia

January 2026 in “ Egyptian Journal of Dermatology and Venerology ”

Mona A. Atwa, Eman E.-S.E.-S. Ibrahim, Azza R.A. El-Zamyan, Hala E.S. Taema, Esraa E.-S.M. Hassan, Mohamed O. Abdalla, Radwa E.-S.M. Marie

TLDR Androgenetic alopecia is linked to insulin resistance and hormonal imbalances.

This study involved 50 patients with androgenetic alopecia (AGA) and 50 healthy controls, examining their hormonal profiles, lipid profiles, insulin resistance, and adipokines. It found that AGA is linked to insulin resistance in both genders and dyslipidemia in males. Females with AGA showed higher serum insulin levels and HOMA-IR scores. Adipokines such as resistin, leptin, and adiponectin were significantly higher in AGA patients, suggesting their role in AGA pathogenesis. Resistin levels negatively correlated with male pattern hair loss, while leptin levels positively correlated with female pattern hair loss. The study emphasizes the importance of evaluating these metabolic and hormonal factors for managing AGA.

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