Insulin Resistance and Its Relationship with High Molecular Weight Adiponectin in Adolescents with Polycystic Ovary Syndrome and a Maternal History of Polycystic Ovary Syndrome

    June 2014 in “ Fertility and Sterility ”
    Sevil Cankaya, Berfu Demir, Sezin Ertürk Aksakal, Berna Dilbaz, Canan Demirtas, Ümit Göktolga
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    TLDR Teens with PCOS and a mom with PCOS have higher insulin resistance and lower adiponectin levels, which could signal early metabolic problems.
    The study, conducted on 40 normal weight adolescents with polycystic ovary syndrome (PCOS) and a maternal history of PCOS, compared to 40 matched controls, found that the PCOS group exhibited significantly higher insulin resistance (IR) and lower high molecular weight (HMW) adiponectin levels, despite having no significant differences in fasting glucose, insulin, and lipid parameters. The presence of biochemical hyperandrogenemia in the PCOS group was associated with even lower HMW adiponectin levels and higher IR scores. These findings suggest that low HMW adiponectin may serve as an early marker for IR and potential metabolic issues in adolescents with PCOS, regardless of their BMI, highlighting the importance of IR screening in this demographic.
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