Assessment of the Relationship Between Serum High Molecular Weight Adiponectin Hormone Levels and Insulin Resistance in Patients with Polycystic Ovary Syndrome
April 2019
in “
Hormone and Metabolic Research
”
TLDR Women with PCOS have lower adiponectin hormone levels and are more likely to have insulin resistance.
The study investigated the link between high molecular weight adiponectin (HMWA) levels and insulin resistance (IR) in 43 women with polycystic ovary syndrome (PCOS) compared to 39 healthy controls. It found that women with PCOS had significantly lower levels of HMWA and higher levels of insulin resistance markers than controls. The results suggested that lower HMWA levels are associated with a greater risk of IR in PCOS patients. However, the study did not find a significant correlation between IR and HMWA levels within the PCOS group. Despite this, the findings imply that reduced HMWA concentrations could potentially predict PCOS or IR in these patients. The study calls for further research to confirm if decreased HMWA levels are a reliable indicator for PCOS and IR, noting the limitation of the small sample size and the use of HOMA-IR instead of the more precise euglycemic-hyperinsulinemic clamp technique for assessing IR.
