The Role of Local and Systemic Leptin in Androgenetic Alopecia

April 2017 in “ Journal of Investigative Dermatology ”

Ching-Wu Chu, Chih-Chung Yang, Liwei Lin, Michael S. Hughes, Y. T. Tsai

androgenetic alopecia leptin hair follicle white adipose tissue systemic circulation local adipose tissue metabolic factors AGA fat tissue

TLDR Higher leptin levels link to hair loss.

Individuals with androgenetic alopecia (AGA) have higher levels of plasma leptin, a signaling molecule from white adipose tissues that modulates hair follicle growth, compared to those without AGA. Leptin can reach the hair follicle via the systemic circulation and from the local adipose tissue of skin. The study suggests that metabolic factors, including leptin, play a role in hair loss diseases. However, further research is needed to understand the clinical implications of leptin in AGA.

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