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research Systemic Circulating Leptin – Aiding New Dimension of Immune-Related Skin Carcinogenesis and Lipid Metabolism

2 citations , April 2023 in “South East European Journal of Immunology”

This pilot study found elevated levels of leptin and other proinflammatory molecules in the serum of melanoma patients, suggesting a potential role for leptin in melanoma progression and a possibility for targeting it in adjuvant therapy.

research 271 The role of local and systemic leptin in androgenetic alopecia

April 2017 in “Journal of Investigative Dermatology”

In this study, higher plasma leptin levels were associated with increased risk and severity of androgenetic alopecia in men, but further research is needed to understand the clinical implications.

research 165 Single-cell RNA sequencing analysis unveils highly active yet diminished CD14+CD16- circulating monocytes, independent of alopecia areata severity

November 2023 in “Journal of Investigative Dermatology”

Highly active but fewer CD14+CD16- monocytes are found in Alopecia Areata patients, regardless of severity.

research INVESTIGATION OF THE EFFECTS OF VISCERAL MASSAGE ON THE MORPHOFUNCTIONAL STATE OF THE SKIN AND SYSTEMIC METABOLISM

March 2026 in “Перспективи та інновації науки”

This study reported that visceral massage improved skin elasticity and metabolic indicators such as glucose and lipid levels, suggesting its potential as a non-invasive method for enhancing skin health and systemic metabolism.

research Penetration and Distribution in Human Skin Focusing on the Hair Follicle

1 citations , July 2005 in “Drugs and the pharmaceutical sciences”

Targeting drugs to hair follicles can treat skin conditions, but reaching deep follicle areas is hard and needs more research.

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community Has any data on systemic absorption of pyrilutamide been published?

1 upvotes 4 months ago

Pyrilutamide shows minimal systemic absorption with low plasma levels and no accumulation, suggesting it's unlikely to cause systemic side effects. However, full results are not yet published in scientific journals.

community Front page article at The New York Times (biggest circulation in the world) regarding notable results with oral minoxidil is a pretty big deal

in Minoxidil 4 years ago

This conversation discusses the potential benefits of using oral minoxidil and finasteride to treat hair loss, with some users sharing their own experiences in taking the medications. Others express concerns about the safety of these treatments.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 3 years ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Is it sufficient to block scalp DHT topically, or is it also necessary to reduce serum DHT? (My Question is Elaborated Below)

in Research/Science 17 upvotes 1 year ago

Topical finasteride can be as effective as oral finasteride for hair regrowth with fewer systemic side effects, but precise dosing is essential. Combining oral dutasteride with topical finasteride is not recommended due to dutasteride's stronger inhibition.

community How come topical finasteride even works at all?

in Finasteride/Dutasteride 29 upvotes 10 months ago

Topical finasteride can effectively reduce scalp DHT by targeting local enzymes, despite less systemic impact compared to oral forms. Combining oral dutasteride with topical finasteride and minoxidil may enhance hair loss prevention, though evidence of its effectiveness is limited.

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