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This pilot study found elevated levels of leptin and other proinflammatory molecules in the serum of melanoma patients, suggesting a potential role for leptin in melanoma progression and a possibility for targeting it in adjuvant therapy.

In this study, higher plasma leptin levels were associated with increased risk and severity of androgenetic alopecia in men, but further research is needed to understand the clinical implications.

Highly active but fewer CD14+CD16- monocytes are found in Alopecia Areata patients, regardless of severity.

This study reported that visceral massage improved skin elasticity and metabolic indicators such as glucose and lipid levels, suggesting its potential as a non-invasive method for enhancing skin health and systemic metabolism.

Targeting drugs to hair follicles can treat skin conditions, but reaching deep follicle areas is hard and needs more research.

This review discusses the advantages and properties of mucoadhesive buccal dosage forms and reports no new clinical findings; the authors emphasize the potential of spanlastics as flexible, biodegradable drug carriers.

This review discusses the potential of microneedles as a pain-free drug delivery method that improves medication distribution while addressing issues associated with traditional transdermal formulations.

The researchers reported that integrating the naturopathic complex Detoxil into standard therapy for chronic dermatoses enhances detoxification, normalizes metabolic markers, and accelerates symptom resolution, suggesting potential benefits for managing skin conditions.

This review summarizes major surveys on Behcet's disease, highlighting its systemic manifestations, with primary morbidity linked to ocular involvement causing severe vision loss or blindness.

This study found that male pattern baldness may serve as a clinical marker for circulating sex hormone levels in men with localized prostate cancer, while chest hair density showed no significant hormone association.

In this study, inducible whole-body Acly-knockout mice revealed that ACLY is essential for skin homeostasis, as its deficiency led to increased sebum production and skin abnormalities, indicating a vital role for cytosolic acetyl-CoA synthesis in preserving skin barrier integrity and systemic lipid regulation.

This study found that using a non-invasive multielectrode array for gene electrotransfer in hairless guinea pigs increased gene expression in the epidermis significantly, with minimal skin changes observed.

This case report describes a patient with unrecognized systemic lupus erythematosus, who experienced myocarditis, polyneuropathy, and pericarditis, and recovered following cardiac support and medication.

This study found that men with androgenetic alopecia had significantly higher plasma leptin levels, which were associated with an increased risk of developing the condition.

This study found that topical patidegib gel significantly shrank basal cell carcinomas in Gorlin syndrome patients without causing the systemic side effects common with oral hedgehog inhibitors.

In this study, copper-doxorubicin liposomes with multidose therapy reduced systemic toxicity compared to ammonium sulfate-loaded doxorubicin liposomes, while combinatorial strategies further enhanced tumor regression and accumulation.

In this study, researchers found that tritiated cortisol was incorporated into the hair of rhesus monkeys primarily as cortisol and cortisone, as well as other metabolites, after systemic administration.

This study reported that squarticles, nanoparticle carriers made from sebum-derived lipids, significantly enhanced minoxidil delivery to hair follicles in vitro, increasing follicular uptake sevenfold and minimizing systemic absorption compared to a free control solution, while showing good skin tolerability.

In this paper, the authors propose that a historical decline in dietary tin intake may contribute to cardiovascular issues and accelerate pattern hair loss by causing copper and zinc depletion, which impairs heart function and scalp circulation.

In this paper, the authors propose that a major reduction in dietary tin over the past century could be linked to increased cardiovascular issues and androgenetic alopecia, hypothesizing that tin deficiency disrupts heart function and scalp circulation by depleting copper and zinc.

In this study, a novel AR protein degrader was shown to reverse DHT-induced hair regrowth delay in a mouse model of androgenetic alopecia, with minimal circulation and potential side effects.

This study provides quantitative evidence that secondary syphilis is highly endemic in Cali, Colombia, and many untreated patients have high numbers of circulating Treponema pallidum spirochetes.

This study found that the angora mouse mutation prolongs the anagen phase, resulting in excessively long hair and follicular abnormalities, without involving circulating hair cycle factors.

This study reviewed the literature to explore the dermatological symptoms associated with Polycystic Ovary Syndrome, such as hirsutism and acne, highlighting the importance of a multidisciplinary approach for optimal management of the syndrome, including controlling circulating androgen levels.

This article reviewed the preparation, application, and characterization of ethosomes as drug delivery transporters and reported that in a double-blind randomized clinical study, ethosomal acyclovir significantly improved all evaluated parameters in skin delivery, highlighting potential for novel therapies.

This study suggests that a biomaterial-based approach using microneedles and ion solutions to deliver SiO3 2− ions may disrupt inflammatory cycles and improve outcomes in inflammatory dilated cardiomyopathy (iDCM).

This review discusses ethosomal delivery systems for topical drugs, highlighting their potential to improve treatment efficacy for conditions like herpes labialis and male pattern baldness, and reports no new clinical results.

This review examines ethosomal structures and their mechanisms as skin delivery systems, outlining preparation methods and applications but presents no new experimental findings.

This paper discusses topical drug delivery targeting the pilosebaceous unit for skin diseases and cosmetic purposes, emphasizing formulation choice and drug physicochemical properties but reports no new findings.

This study reports that spironolactone, a potassium-sparing diuretic with antiandrogenic activity, effectively improves hair density, reduces shedding, and stabilizes symptoms in female pattern hair loss, though symptoms often recur after discontinuation, suggesting the need for sustained therapy.