Expression of Three Adipokines (Adiponectin, Leptin, and Resistin) in Normal Canine Skin: A Pilot Study

This pilot study investigated the expression of three adipokines—adiponectin, leptin, and resistin—in normal canine skin. Using punch biopsy samples from a healthy 8-year-old English setter, the researchers found that all three adipokines were expressed in the cytoplasm and sometimes the nucleus of keratinocytes across all epidermal layers, the outer root sheath of hair follicles, and sebaceous glands. This study was the first to report on the expression of these adipokines in canine skin, providing a foundation for future research on their roles in canine skin health and disease.