Expression of Three Adipokines (Adiponectin, Leptin, and Resistin) in Normal Canine Skin: A Pilot Study

    February 2019 in “ Journal of comparative pathology ”
    Thomas Brément, Chloé Le Cossec, Carel W. le Roux, Anne‐Chantal Knol, Brigitte Dréno, Amir Khammari, P. Bourdeau, Vincent Bruet
    TLDR The three adipokines—leptin, adiponectin, and resistin—are present in various cells of normal dog skin.
    This pilot study investigated the expression of three adipokines—adiponectin, leptin, and resistin—in normal canine skin. Using punch biopsy samples from a healthy 8-year-old English setter, the researchers found that all three adipokines were expressed in the cytoplasm and sometimes the nucleus of keratinocytes across all epidermal layers, the outer root sheath of hair follicles, and sebaceous glands. This study was the first to report on the expression of these adipokines in canine skin, providing a foundation for future research on their roles in canine skin health and disease.
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