Sex Hormones and Acne: The Role of the Skin as an Endocrine Organ

    October 2016 in “ Clinics in dermatology ”
    Jun Qiang, Tao Tao, Tingting Hu … WenChieh Chen
    Studysummary This review discusses the hormonal and genetic factors influencing acne development, emphasizing the role of androgens and insulin signaling but reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 29

    1. Diagnostic Criteria for PCOS: Is There a Need for a Rethink? Best Practice & Research in Clinical Obstetrics & Gynaecology · 2016
    2. Skin Expression of Mammalian Target of Rapamycin and Forkhead Box Transcription Factor O1, and Serum Insulin-Like Growth Factor-1 in Patients with Acne Vulgaris and Their Relationship with Diet British Journal of Dermatology · 2016
    3. Sebocytes Differentially Express and Secrete Adipokines Experimental Dermatology · 2015
    4. Linking Diet to Acne Metabolomics, Inflammation, and Comedogenesis: An Update Clinical, Cosmetic and Investigational Dermatology · 2015
    5. The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells Journal of Investigative Dermatology · 2015
    6. Acne: A Potential Skin Marker of Internal Disease Clinics in Dermatology · 2015
    7. Androgens Induce Sebaceous Differentiation in Sebocyte Cells Expressing a Stable Functional Androgen Receptor Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 2015
    8. Polycystic Ovary Syndrome: A Review for Dermatologists Journal of the American Academy of Dermatology · 2014
    9. Effects of Hyperandrogenism and High Body Mass Index on Acne Severity in Women PubMed · 2014
    10. Expression of Steroidogenic Enzymes in Human Sebaceous Glands Journal of Endocrinology/Journal of endocrinology · 2014
    11. Cross-Sex Hormone Therapy in Trans Persons Is Safe and Effective at Short-Term Follow-Up: Results from the European Network for the Investigation of Gender Incongruence The Journal of Sexual Medicine · 2014
    12. Steroidogenesis of the Testis: New Genes and Pathways Annales d'endocrinologie · 2014
    13. Regional Difference in Sebum Production by Androgen Susceptibility in Human Facial Skin Experimental Dermatology · 2013
    14. C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis Cell reports · 2013
    15. CYP21A2 Genotypes Do Not Predict the Severity of Hyperandrogenic Manifestations in the Nonclassical Form of Congenital Adrenal Hyperplasia Hormone and Metabolic Research · 2013
    16. Contributions of Peroxisome Proliferator-Activated Receptor β/δ to Skin Health and Disease BioMolecular Concepts · 2012
    17. Hepatotoxicity with Low- and Ultralow-Dose Flutamide: A Surveillance Study on 203 Hyperandrogenic Young Females Fertility and Sterility · 2012
    18. Sex Steroid Synthesis in Human Skin In Situ: The Roles of Aromatase and Steroidogenic Acute Regulatory Protein in the Homeostasis of Human Skin Molecular and Cellular Endocrinology · 2012
    19. Effects of an Oral Contraceptive Containing Chlormadinone Acetate and Ethinylestradiol on Hair and Skin Quality in Women Wishing to Use Hormonal Contraception Journal of the European Academy of Dermatology and Venereology · 2012
    20. Polycystic Ovary Syndrome and Acne Skin therapy letter · 2011
    21. Acne-Associated Syndromes: Models for Better Understanding of Acne Pathogenesis Journal of The European Academy of Dermatology and Venereology · 2010
    22. Effect of Dihydrotestosterone on the Upregulation of Inflammatory Cytokines in Cultured Sebocytes Archives of Dermatological Research · 2009
    23. Biosynthesis of Dihydrotestosterone by a Pathway That Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line Journal of Investigative Dermatology · 2009
    24. Role of FGFR2-Signaling in the Pathogenesis of Acne Dermato-endocrinology · 2009
    25. Hormones and the Pilosebaceous Unit Dermato-endocrinology · 2009
    26. Prostaglandin Metabolism in Human Hair Follicle Experimental Dermatology · 2007
    27. Sexual Hormones in Human Skin Hormone and metabolic research · 2007
    28. Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2006
    29. Sex Steroid Hormone Receptors in Human Skin Appendages and Their Neoplasms Endocrine Journal · 2005