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      A Case of Unusual Comedogenesis in Alopecia Totalis

      research A case of unusual comedogenesis in alopecia totalis

      June 2022 in “Indian Dermatology Online Journal”
      This case report describes a 19-year-old male with alopecia totalis and comedones over the bald scalp, suggesting the importance of terminal hair for sebum drainage to prevent preliminary acne lesions.

      research Sex hormones and acne

      76 citations , October 2016 in “Clinics in dermatology”
      This review discusses the hormonal and genetic factors influencing acne development, emphasizing the role of androgens and insulin signaling but reports no new clinical results.

      research Unraveling the Comedone Switch through Single-Cell Resolution of Human Acne Lesions

      July 2026 in “bioRxiv (Cold Spring Harbor Laboratory)”
      This study used single-cell transcriptomic analysis to identify a specific cell population in acne patients' non-lesional skin, providing evidence for the comedone switch hypothesis by suggesting a shift towards infundibular differentiation at the expense of sebaceous gland maintenance.

      research Comedone formation: Etiology, clinical presentation, and treatment

      103 citations , September 2004 in “Clinics in dermatology”
      This article discusses methods to measure comedogenesis in acne through the presence of microcomedones and reports no new clinical results; the authors outline a skin surface biopsy technique using cyanoacrylate gel.