Contributions of Peroxisome Proliferator-Activated Receptor β/δ to Skin Health and Disease

November 2012 in “ BioMolecular Concepts ”

Alexandra Montagner, Walter Wahli

peroxisome proliferator-activated receptor β/δ PPAR β/δ keratinocyte differentiation sebocyte differentiation hair follicle growth wound healing inflammatory skin diseases psoriasis acne vulgaris skin cancer tumor growth modifier

TLDR PPAR β/δ is important for skin health and disease treatment, but more research is needed.

The document reviewed the role of peroxisome proliferator-activated receptor β/δ (PPAR β/δ) in skin health and disease, highlighting its involvement in keratinocyte differentiation, sebocyte differentiation, hair follicle growth, and wound healing. PPAR β/δ was implicated in inflammatory skin diseases like psoriasis and acne vulgaris, with its modulation offering potential therapeutic strategies. It played ambivalent roles in skin cancer, acting as a tumor growth modifier with context-specific effects. The research emphasized PPAR β/δ as a significant target for understanding and treating various skin conditions, although further research was needed to fully understand its complex functions and context-specific activities.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community You will lose hair if your prostaglandins aren't in balance

in Research/Science 54 upvotes 9 months ago

Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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