Engineered Skin Substitute Regenerates Skin with Hair Follicle Formation

    April 2021 in “ Biomedicines ”
    Jinmei Wang, Xiaoxiao Wang, Jundong Xie … Yaojiong Wu
    Studysummary This study found that engineered skin substitutes made with skin-derived precursors and epidermal stem cells can regenerate hair follicles after grafting into nude mice.
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    Research cited in this study 14

    1. Early-Stage Bilayer Tissue-Engineered Skin Substitute Formed by Adult Skin Progenitor Cells Produces an Improved Skin Structure In Vivo Stem cell research & therapy · 2020
    2. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    3. A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro? Cells · 2020
    4. Tissue Engineering Strategies for Human Hair Follicle Regeneration: How Far From a Hairy Goal? Stem Cells Translational Medicine · 2019
    5. TSA Restores Hair Follicle-Inductive Capacity of Skin-Derived Precursors Scientific Reports · 2019
    6. Fabrication of Chimeric Hair Follicles for Skin Tissue Engineering Methods in molecular biology · 2019
    7. Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors Stem Cells Translational Medicine · 2016
    8. Self-Assembling Peptide Hydrogel Scaffolds Support Stem Cell-Based Hair Follicle Regeneration Nanomedicine: Nanotechnology, Biology and Medicine · 2016
    9. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    10. Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach Journal of Investigative Dermatology · 2013
    11. Characterization of Hair Follicle Development in Engineered Skin Substitutes PLOS ONE · 2013
    12. Dynamic Signals for Hair Follicle Development and Regeneration Stem Cells and Development · 2011
    13. SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells Cell stem cell · 2009
    14. Scratching the Surface of Skin Development Nature · 2007

    Related research 9

    1. Wound-Induced Hair Follicle Neogenesis: A New Perspective on Hair Follicle Regeneration in Adult Mammals PubMed · 2020
    2. Induction of Hair Follicle Neogenesis with Cultured Mouse Dermal Papilla Cells in De Novo Regenerated Skin Tissues Journal of Tissue Engineering and Regenerative Medicine · 2019
    3. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    4. Hair-Follicle Dermal Papilla and Sheath Fibroblasts Provide a Supportive Microenvironment for Human Skin Regeneration British journal of dermatology/British journal of dermatology, Supplement · 2017
    5. Augmentation of HGF Signaling: Potential for Enhancing Hair Follicle Neogenesis and Development in Bioengineered Skin Journal of Investigative Dermatology · 2016
    6. Epigenetic Control of Skin and Hair Regeneration After Wounding Experimental Dermatology · 2014
    7. A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles Experimental Dermatology · 2014
    8. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    9. Dermal Papilla-Induced Hair Differentiation of Adult Epithelial Stem Cells from Human Skin Physiological Genomics · 2004