Fabrication of Chimeric Hair Follicles for Skin Tissue Engineering

    January 2019 in “ Methods in molecular biology ”
    Andrea L. Lalley, Steven T. Boyce
    Studysummary This chapter describes methods for creating engineered skin substitutes with chimeric hair follicles using human and murine cell grafts in immunodeficient mice, but reports no clinical outcomes.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 8

    1. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    2. Dissociated Human Dermal Papilla Cells Induce Hair Follicle Neogenesis in Grafted Dermal-Epidermal Composites Journal of Investigative Dermatology · 2013
    3. Characterization of Hair Follicle Development in Engineered Skin Substitutes PLOS ONE · 2013
    4. Morphogenesis of Chimeric Hair Follicles in Engineered Skin Substitutes With Human Keratinocytes and Murine Dermal Papilla Cells Experimental Dermatology · 2012
    5. Assessment of Replication Rates of Human Keratinocytes in Engineered Skin Substitutes Grafted to Athymic Mice Wound Repair and Regeneration · 2012
    6. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    7. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    8. Hair Follicle Embryogenesis in Humans: Characterization of Events In Vivo and In Vitro PubMed · 1991

    Related research 8

    1. Incorporation of Hair Follicles in 3D Bioprinted Models of Human Skin Science Advances · 2023
    2. Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes Journal of St. Marianna University · 2022
    3. A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles Experimental Dermatology · 2014
    4. Characterization of Hair Follicle Development in Engineered Skin Substitutes PLOS ONE · 2013
    5. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    6. Study on Hair Follicle Formation Induced by Dermal Papilla Cells Chinese Journal of Reparative and Reconstructive Surgery · 2003
    7. Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae Experimental Dermatology · 2001
    8. Role of Hair Papilla Cells in Induction and Regeneration Processes of Hair Follicles Wound Repair and Regeneration · 1998