Hair Regrowth

April 1998 in “ Dermatologic Clinics ”

Jerry Shapiro, Vera H. Price

androgenetic alopecia alopecia areata finasteride antiandrogens minoxidil intralesional corticosteroids systemic corticosteroids topical immunotherapy DPCP targeted immunomodulatory agents gene therapy phototherapy AGA Propecia Rogaine corticosteroids diphenylcyclopropenone

From the encyclopedia

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Studysummary This review discusses the advancements in understanding and treating androgenetic alopecia and alopecia areata but reports no clinical findings; the authors emphasize the need for further research on molecular control mechanisms.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

48 / 48 results

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research Whole Hair Follicle Culture

57 citations , October 1996 in “Dermatologic clinics”

This study found that using hyaluronic acid microneedles to deliver minoxidil significantly reduced hair loss in chemotherapy-induced alopecia mice, with only 10% of the dose used in topical applications.

research The Use of Dermal Papilla Cells in Studies of Normal and Abnormal Hair Follicle Biology

19 citations , October 1996 in “Dermatologic Clinics”

This review discusses using cultured dermal papilla cells to investigate hair follicle biology, emphasizing their potential to inform treatments, but reports no new clinical results.

research Antiandrogen And Hormonal Treatment Of Acne

38 citations , October 1996 in “Dermatologic Clinics”

This review discusses inflammatory and medication-related skin conditions associated with kidney disease and emphasizes the importance of timely referral to nephrology, reporting no new clinical results.

research Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia

143 citations , October 1996 in “Dermatologic Clinics”

Too much androgen can cause hair loss; finasteride may help.

research Guidelines of Care for Androgenetic Alopecia

37 citations , September 1996 in “Journal of The American Academy of Dermatology”

Treat genetic hair loss early with FDA-approved medications and consider hair transplantation.

research The 5 Alpha-Reductase System and Its Inhibitors

124 citations , January 1996 in “Dermatology”

This article reviews the biochemical properties of 5 alpha-reductase isoforms and highlights the limited dermatological use of inhibitors like finasteride, especially for type 1 isozyme-targeting agents, while suggesting further clinical exploration.

research PUVA Treatment of Alopecia Areata Partialis, Totalis, and Universalis: Audit of 10 Years' Experience at St John's Institute of Dermatology

105 citations , December 1995 in “British journal of dermatology/British journal of dermatology, Supplement”

This retrospective study concluded that PUVA treatment is generally ineffective for alopecia areata, with low effective success rates for partialis, totalis, and universalis types.

research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness

61 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

research Androgenetic Alopecia in the Female

82 citations , March 1994 in “Archives of Dermatology”

This study found that a 2% topical minoxidil solution significantly increased hair regrowth compared to placebo in women with androgenetic alopecia over 32 weeks.

research Minoxidil

24 citations , January 1993 in “Dermatologic Clinics”

Minoxidil effectively treats hair loss, works better for women, and requires consistent use.

research Systemic Steroids With or Without 2% Topical Minoxidil in the Treatment of Alopecia Areata

101 citations , November 1992 in “Archives of Dermatology”

In this study, tapering prednisone followed by 2% topical minoxidil helped limit hair loss in some patients with alopecia areata, with 30% to 47% showing over 25% hair regrowth initially.

research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

1040 citations , October 1992 in “The New England Journal of Medicine”

In this study, 5 mg of finasteride per day significantly improved urinary symptoms and reduced prostate volume in men with benign prostatic hyperplasia, but increased the risk of sexual dysfunction.

research Topical Minoxidil in Alopecia Areata: No Effect on the Perifollicular Lymphoid Infiltration

33 citations , July 1992 in “Journal of Investigative Dermatology”

Minoxidil doesn't affect perifollicular lymphoid infiltration in alopecia areata patients.

research Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp

124 citations , April 1992 in “Journal of Endocrinology/Journal of endocrinology”

This study observed that cells from androgen-sensitive areas like the beard and scrotum showed higher androgen receptor levels compared to those from non-balding scalp areas, supporting the role of dermal papilla in follicle growth responses to androgens.

research Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

40 citations , February 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Taking finasteride pills and using minoxidil lotion together can help grow hair.

research Steroid Chemistry and Hormone Controls During the Hair Follicle Cycle

34 citations , December 1991 in “Annals of the New York Academy of Sciences”

This study found that while the steroid mechanisms influencing androgenetic alopecia may be similar for men and women, differences in enzyme activity and receptor content could explain their varied clinical presentations.

research Alopecia Areata in Children: Response to Treatment with Diphencyprone

84 citations , August 1991 in “British Journal of Dermatology”

This study found that 67% of children treated with diphencyprone for alopecia areata or alopecia totalis regrew scalp hair, with 33% achieving complete regrowth.

research The Clinical Development of a 5α-Reductase Inhibitor, Finasteride

211 citations , November 1990 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride effectively treats BPH, but needs more trials to understand potential.

research Five-Year Follow-Up of Men with Androgenetic Alopecia Treated with Topical Minoxidil

70 citations , April 1990 in “Journal of The American Academy of Dermatology”

Minoxidil treatment increased hair growth for up to 5 years, requiring twice daily application.

research The Management of Androgenetic Alopecia in Women

8 citations , January 1989 in “Journal of Dermatological Treatment”

This text talks about how to treat hair loss in women. It suggests different options and stresses the importance of support.

research Clinical Applications of Antiandrogens

29 citations , October 1988 in “Journal of Steroid Biochemistry”

This review discusses the use of antiandrogens for various conditions like prostate cancer and highlights their potential benefits in remission rates and symptom improvement, but it reports no new clinical results.

research Evaluation of Anthralin in the Treatment of Alopecia Areata

109 citations , November 1987 in “Archives of dermatology”

In this study, 0.5%-1.0% anthralin cream led to a cosmetic response in 25% of patients with severe alopecia areata, despite common side effects like pruritus and erythema.

research Treatment of Alopecia Areata With Squaric Acid Dibutylester

42 citations , August 1987 in “Archives of Dermatology”

In this study, 28.5% of patients with extensive alopecia areata had complete hair regrowth during treatment with squaric acid dibutylester, with outcomes linked to shorter alopecia duration and prompt dermatitis development.

research Topical Minoxidil in Male Pattern Baldness: Effects of Discontinuation of Treatment

57 citations , July 1987 in “Journal of The American Academy of Dermatology”

In this study, minoxidil treatment was associated with an increase in nonvellus scalp hairs, but this effect was not sustained once the treatment was stopped.

research Action of Topical Minoxidil in the Bald Stump-Tailed Macaque

78 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil promotes hair growth but stops working when discontinued.

research Double-Blind, Placebo-Controlled Evaluation of Topical Minoxidil in Extensive Alopecia Areata

104 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil helps hair growth in 63.6% of alopecia patients, with 27.3% having excellent results.

research Topical Minoxidil (3%) in Extensive Alopecia Areata, Including Long-Term Efficacy

54 citations , March 1987 in “Journal of The American Academy of Dermatology”

In this study, 3% topical minoxidil showed some efficacy in hair regrowth for patients with extensive alopecia areata, especially those with less than total scalp hair loss, but did not lead to complete remission.

research Long-Term Follow-Up of Men with Male Pattern Baldness Treated with Topical Minoxidil

51 citations , March 1987 in “Journal of The American Academy of Dermatology”

This study found that twice-daily application of 3% topical minoxidil maintained a higher nonvellus hair count compared to once-daily application over 2 years and 9 months in men with male pattern baldness.

research Use of Topical Minoxidil as a Possible Adjunct to Hair Transplant Surgery

28 citations , March 1987 in “Journal of The American Academy of Dermatology”

This study observed that two out of twelve patients showed hair growth without the usual shedding after hair transplant surgery when treated with topical minoxidil, suggesting its potential as an adjunctive therapy during recovery.

research Topical Minoxidil in Extensive Alopecia Areata, Including 3-Year Follow-Up

34 citations , January 1987 in “Dermatology”

In this study, topical minoxidil was found to be an effective, safe, and easy treatment for individuals with alopecia areata affecting 25–99% of the scalp, but less effective for total scalp hair loss.

research Topical Tretinoin for Hair Growth Promotion

73 citations , October 1986 in “Journal of the American Academy of Dermatology”

This study found that a combination of topical tretinoin and 0.5% minoxidil resulted in terminal hair regrowth in 66% of subjects with androgenetic alopecia over one year.

research Dose-Response Study of Topical Minoxidil in Male Pattern Baldness

58 citations , July 1986 in “Journal of The American Academy of Dermatology”

Lowest effective minoxidil concentration is 1%, but 2% works better for male pattern baldness.

research Topical Minoxidil Dose-Response Effect in Alopecia Areata

54 citations , February 1986 in “Archives of Dermatology”

This study found that 5% topical minoxidil solution led to greater hair regrowth in severe alopecia areata patients compared to 1% minoxidil, although most regrowth was not cosmetically acceptable.

research Cyclic Dynamics of Hair Follicles and the Effect of Minoxidil on the Bald Scalps of Stumptailed Macaques

54 citations , June 1985 in “American Journal of Dermatopathology”

This abstract does not provide specific findings or results.

research The Effects of Two Doses of Spironolactone on Serum Androgens and Anagen Hair in Hirsute Women

142 citations , February 1985 in “Fertility and sterility”

This study found that spironolactone reduced serum androstenedione and anagen hair shaft diameter in hirsute patients but did not significantly alter unbound testosterone levels, suggesting its effects are primarily peripheral.

research Oral Spironolactone Therapy for Female Patients with Acne, Hirsutism, or Androgenic Alopecia

101 citations , January 1985 in “British Journal of Dermatology”

This article discusses oral spironolactone therapy for female patients with acne, hirsutism, or androgenic alopecia and reports no new clinical results.

research The Inheritance Of Common Baldness: To Be Or Not To Be?

203 citations , November 1984 in “Journal of the American Academy of Dermatology”

This study presents evidence suggesting that androgenetic alopecia is most likely inherited through a polygenic model, challenging the traditional view that it is caused by a simple Mendelian autosomal dominant gene.

research Effective Medical Treatment for Common Baldness in Women

43 citations , July 1984 in “Clinical and Experimental Dermatology”

This study found that women with common baldness treated with cyclical antiandrogen therapy for 52 weeks experienced increased hair density and a higher percentage of hairs in the anagen growth phase.

research Effect of Minoxidil on Cultured Keratinocytes

72 citations , December 1983 in “Journal of Investigative Dermatology”

Minoxidil helps hair cells live longer and grow longer.

research Local Therapy of Androgenetic Alopecia with 17α-Estradiol

54 citations , January 1980 in “Dermatology”

This study found that topical application of hair lotion containing 17α-estradiol may reduce androgenetic hair loss, as 63% of treated patients showed a decrease in telogen hairs compared to 37% in the control group.

research Treatment of Hirsutism, Acne, and Alopecia with Cyproterone Acetate

39 citations , January 1980 in “Dermatology”

In this study, cyproterone acetate with ethinyl estradiol effectively treated acne, hirsutism, and alopecia in women, with the highest success in acne and rare side effects similar to estrogen contraceptives.

research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

666 citations , September 1977 in “British Journal of Dermatology”

This article presents a classification system for stages of female-pattern androgenetic alopecia to aid early diagnosis and mentions existing systems for rare male-pattern cases, but reports no new clinical results.

research Pharmacology and Potential Use of Cyproterone Acetate

129 citations , January 1977 in “Hormone and metabolic research”

Cyproterone Acetate effectively treats androgen-related conditions and is used in prostate cancer therapy and hormone therapy for transgender women.

research Testosterone Metabolism in the Skin

74 citations , November 1975 in “Archives of dermatology”

This review discusses testosterone metabolism in human skin and its role in androgenetic skin disorders, suggesting that temporary increases in dihydrotestosterone may lead to these conditions.

research Use of Cyproterone Acetate in the Treatment of Acne, Hirsutism, and Virilism

232 citations , June 1975 in “Journal of Steroid Biochemistry”

In this study, a treatment regimen combining cyproterone acetate and ethinyl estradiol significantly improved acne and seborrhoea in most women after three months, but had varied effects on hirsutism and alopecia.

research Treatment of Alopecia Areata With Steroid Solution

30 citations , December 1972 in “Archives of dermatology”

This report examines efforts to enhance the efficacy of topical steroids for alopecia areata using penetration-enhancing vehicles and exceptionally high concentrations, noting systemic steroids often lead to relapses and toxicity.

research Alopecia Totalis: Significant Hair Regrowth with Fluocinolone Acetonide Cream

22 citations , March 1963 in “Archives of dermatology”

This case report describes hair regrowth in a patient with alopecia totalis using fluocinolone acetonide cream applied under thin plastic films.