Evaluation of the Efficacy and Safety of Topical Procyanidin B2 and Placebo in the Treatment of Androgenetic Alopecia in Men: A Randomized, Double-Blind, Placebo-Controlled Study

    January 2022 in “ Turk Dermatoloji Dergisi ”
    Yıldıray Yeniay, Ercan Arca
    Studysummary This placebo-controlled study found that topical procyanidin B2 significantly increased total and anagen hair counts in men with androgenetic alopecia over 16 weeks compared to placebo, suggesting it as an effective and safe treatment option.
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    Research cited in this study 27

    1. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    2. Dexpanthenol May Be a Novel Treatment for Male Androgenetic Alopecia: Analysis of Nine Cases Dermatologic Therapy · 2020
    3. Serum Biotin and Zinc in Male Androgenetic Alopecia Journal of Cosmetic Dermatology · 2019
    4. Efficacy of Off-Label Topical Treatments for the Management of Androgenetic Alopecia: A Review Clinical Drug Investigation · 2019
    5. Efficacy and Safety of a New 5% Minoxidil Formulation in Male Androgenetic Alopecia: A Randomized, Placebo-Controlled, Double-Blind, Noninferiority Study Journal of Cosmetic Dermatology · 2018
    6. The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride Journal of Dermatological Treatment · 2013
    7. Topical Melatonin for Treatment of Androgenetic Alopecia International Journal of Trichology · 2012
    8. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    9. Association of Androgenetic Alopecia with Metabolic Syndrome in Men: A Community-Based Survey British Journal of Dermatology · 2010
    10. Profiling the Response of Human Hair Follicles to Ultraviolet Radiation Journal of Investigative Dermatology · 2009
    11. Efficacy of 5% Minoxidil Versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss American Journal of Clinical Dermatology · 2007
    12. Procyanidin Oligomers Counteract TGF-β1- and TGF-β2-Induced Apoptosis in Hair Epithelial Cells: An Insight into Their Mechanisms Skin pharmacology and physiology · 2006
    13. Investigation of the Topical Application of Procyanidin Oligomers from Apples to Identify Their Potential Use as a Hair-Growing Agent Journal of cosmetic dermatology · 2005
    14. An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia Dermatology · 2004
    15. Is Androgenic Alopecia a Result of Endocrine Effects on the Vasculature? Medical Hypotheses · 2003
    16. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    17. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    18. Procyanidin B-2 Extracted from Apples Promotes Hair Growth: A Laboratory Study British journal of dermatology/British journal of dermatology, Supplement · 2002
    19. The First Clinical Trial of Topical Application of Procyanidin B-2 to Investigate Its Potential as a Hair Growing Agent PTR. Phytotherapy research/Phytotherapy research · 2001
    20. Investigation of Topical Application of Procyanidin B-2 from Apple to Identify Its Potential Use as a Hair Growing Agent Phytomedicine · 2000
    21. Androgenetic Alopecia and Microinflammation International Journal of Dermatology · 2000
    22. A Case of Acute Myocardial Infarction Associated with Topical Use of Minoxidil for Treatment of Baldness Japanese Heart Journal · 2000
    23. Androgenetic Alopecia: Causes, Diagnosis, and Treatment Options International Journal of Dermatology · 1999
    24. Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1999
    25. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    26. Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy Molecular Medicine Today · 1996
    27. Topical Minoxidil in Early Androgenetic Alopecia Journal of The American Academy of Dermatology · 1987

    Related research 9

    1. A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss PubMed · 2022
    2. Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil JAAD case reports · 2022
    3. Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis Journal of Cosmetic Dermatology · 2020
    4. Oral Minoxidil Improves Background Hair Thickness in Lichen Planopilaris Journal of The American Academy of Dermatology · 2020
    5. Pustular Dermatosis of the Scalp Due to Topical Minoxidil 5% 2018
    6. Scalp Psoriasiform Contact Dermatitis with Acute Telogen Effluvium Due to Topical Minoxidil Treatment Skin appendage disorders · 2015
    7. Alopecia Areata: Evidence-Based Treatments Seminars in cutaneous medicine and surgery · 2009
    8. Use of Topical Minoxidil Therapy for Androgenetic Alopecia in Women International Journal of Dermatology · 1993
    9. Treatment of Female Androgenetic Alopecia with Minoxidil 2% International Journal of Dermatology · 1992