A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia

    May 2020 in “ Stem Cells Translational Medicine ”
    Young Jin Tak, Sang Yup Lee, Jun-Sik Cho, Young Ho Kim
    Studysummary In this randomized clinical trial, the authors reported that adipose-derived stem cell constituent extract topical solution increased hair density and thickness in patients with androgenetic alopecia over 16 weeks compared to placebo.
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    Research cited in this study 34

    1. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    2. Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation Biomedicines · 2019
    3. Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature and Proposed Treatment Protocol International Journal of Women's Dermatology · 2018
    4. Minoxidil in the Treatment of Androgenetic Alopecia Dermatologic Therapy · 2018
    5. Minoxidil Promotes Hair Growth Through Stimulation of Growth Factor Release from Adipose-Derived Stem Cells International Journal of Molecular Sciences · 2018
    6. Perception of Hair Loss and Education Increases Treatment Willingness in Patients With Androgenetic Alopecia: A Population-Based Study Annals of Dermatology · 2018
    7. The Study of Growth Factors in Patients with Androgenic Alopecia Biomedical and Pharmacology Journal · 2017
    8. Up-To-Date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss Current stem cell research & therapy · 2017
    9. Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss Stem cell investigation · 2017
    10. Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems International Journal of Molecular Sciences · 2017
    11. Sexual Side Effects of 5-Alpha-Reductase Inhibitors Finasteride and Dutasteride: A Comprehensive Review Dermatology Online Journal · 2017
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    14. Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study International Journal of Dermatology · 2015
    15. Prospect of Stem Cell Conditioned Medium in Regenerative Medicine BioMed Research International · 2014
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    17. Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial Evidence-based Complementary and Alternative Medicine · 2014
    18. The Latest Advance in Hair Regeneration Therapy Using Proteins Secreted by Adipose-Derived Stem Cells The American Journal of Cosmetic Surgery · 2012
    19. Quality of Life Assessment in Male Patients with Androgenetic Alopecia: Results of a Prospective, Multicenter Study Annals of Dermatology · 2012
    20. Characteristics of Androgenetic Alopecia in Asian Populations Annals of Dermatology · 2012
    21. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men Journal der Deutschen Dermatologischen Gesellschaft · 2011
    22. Hair Growth and Rejuvenation: An Overview Journal of Dermatological Treatment · 2010
    23. Targeting to the Hair Follicles: Current Status and Potential Journal of dermatological science · 2010
    24. Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion Biomedical research · 2010
    25. Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells Journal of Dermatological Science · 2009
    26. A New Classification of Pattern Hair Loss That Is Universal for Men and Women: Basic and Specific (BASP) Classification Journal of The American Academy of Dermatology · 2007
    27. PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles Journal of Dermatological Science · 2006
    28. A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    29. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    30. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    31. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    32. Hepatocyte Growth Factor Activator Expressed in Hair Follicles Is Involved in In Vitro HGF-Dependent Hair Follicle Elongation Journal of Dermatological Science · 2001
    33. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
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    2. Topical Diclofenac 3% Gel for Actinic Keratosis May Induce Terminal Hair in Male Androgenetic Alopecia: A Report of Three Cases Journal of skin and stem cell · 2015
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