Topical Diclofenac 3% Gel for Actinic Keratosis May Induce Terminal Hair in Male Androgenetic Alopecia: A Report of Three Cases

    December 2015 in “ Journal of skin and stem cell ”
    Helena Collgros, Joaquin Sola Ortigosa, Maribel Iglesias-Sancho
    Image of study
    TLDR Using a gel called Diclofenac can potentially cause hair to grow back in bald spots in older men.
    In 2015, a study was conducted on three male patients with actinic keratosis (AK) and androgenetic alopecia (AGA), who were treated with topical 3% diclofenac gel. The patients, aged 73, 77, and 79, showed terminal hair growth on previously bald areas of the scalp after four to six months of treatment. The authors hypothesized that the inhibition of the COX-2 enzyme by diclofenac might act over the perifollicular micro-inflammation and the prostaglandins imbalance observed in AGA, leading to hair growth. This was the first reported case of hair growth due to topical diclofenac treatment. However, the study had limitations including the small number of patients and lack of laboratory testing or specific imaging surveys. Further research was suggested to confirm these findings and explore the mechanisms of micro-inflammation and prostaglandins regulation in AGA.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 15 results

      community Bryan Johnson just dropped his anti hair loss formula

      in Treatment  339 upvotes 10 months ago
      Bryan Johnson shared his hair loss treatment, which mainly relies on minoxidil and finasteride. Some users are skeptical of his results, while others appreciate his efforts in anti-aging and hair loss research.

      community Interested about what other adjunct therapies people are trying & whats working?

      in Treatment  8 upvotes 8 months ago
      The conversation discusses alternative hair loss treatments beyond the commonly used Minoxidil and Finasteride. One user is trying diclofenac gel, caffeine + antioxidant serum, finasteride, ketoconazole shampoo, and has stopped using Minoxidil due to ineffectiveness, while another user has adopted lifestyle changes like exercise, diet, stress reduction, and topical caffeine, along with scalp massages and microneedling.

      community Exploring Bryan Johnson's Hair Routine In Detail

      in Research/Science  64 upvotes 11 months ago
      Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

    Similar Research

    5 / 230 results