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    Meta-Analysis Identifies Novel Risk Loci and Yields Systematic Insights into the Biology of Male-Pattern Baldness

    March 2017 in “ Nature communications ”
    Markus M. Nöthen, Christine Herold, Lara M. Hochfeld … Markus M. Nöthen
    Studysummary This study identified 63 genetic loci associated with male-pattern baldness, uncovering genes and pathways that may help develop treatments and suggesting its connection to other human conditions.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 33

    1. Illness Perception in Patients with Androgenetic Alopecia and Alopecia Areata in China Journal of Psychosomatic Research · 2016
    2. Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Journal of Investigative Dermatology · 2016
    3. Hunting the Genes in Male-Pattern Alopecia: How Important Are They, How Close Are We and What Will They Tell Us? Experimental Dermatology · 2016
    4. Hair, Hormones, and High-Risk Prostate Cancer Journal of Clinical Oncology · 2014
    5. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    6. Alopecia and Its Association with Coronary Heart Disease and Cardiovascular Risk Factors: A Meta-Analysis International Journal of Cardiology · 2014
    7. Neuroendocrinology of the Hair Follicle: Principles and Clinical Perspectives Trends in Molecular Medicine · 2014
    8. FGF5 Is a Crucial Regulator of Hair Length in Humans Proceedings of the National Academy of Sciences of the United States of America · 2014
    9. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    10. Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia Expert Opinion on Therapeutic Targets · 2014
    11. An Overview of Alopecias Cold Spring Harbor Perspectives in Medicine · 2014
    12. Estrone Sulfate Source of Estrone and Estradiol Formation in Isolated Human Hair Roots: Identification of a Pathway Linked to Hair Growth Phase and Subject to Site, Gender, and Age-Related Modulations The Journal of Clinical Endocrinology & Metabolism · 2014
    13. Evidence for a Polygenic Contribution to Androgenetic Alopecia British Journal of Dermatology · 2013
    14. Androgenetic Alopecia and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2013
    15. Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology Journal of Investigative Dermatology · 2013
    16. Androgen Actions on the Human Hair Follicle: Perspectives Experimental Dermatology · 2012
    17. Genome-Wide Association Study Identifies a New Locus JMJD1C at 10q21 That May Influence Serum Androgen Levels in Men Human molecular genetics online/Human molecular genetics · 2012
    18. Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases PLOS Genetics · 2012
    19. Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness British Journal of Dermatology · 2011
    20. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    21. Androgenetic Alopecia as an Early Marker of Benign Prostatic Hyperplasia Journal of The American Academy of Dermatology · 2011
    22. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    23. Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11 Nature Genetics · 2008
    24. Male-Pattern Baldness Susceptibility Locus at 20p11 Nature Genetics · 2008
    25. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    26. The Hair Follicle as an Estrogen Target and Source Endocrine Reviews · 2006
    27. Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men Mayo Clinic Proceedings · 2005
    28. The Role of Melatonin in Neuroectodermal-Mesodermal Interactions: The Hair Follicle Synthesizes Melatonin and Expresses Functional Melatonin Receptors ˜The œFASEB journal · 2005
    29. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005
    30. Genetic Basis of Male Pattern Baldness Journal of Investigative Dermatology · 2003
    31. Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003
    32. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    33. Improvement in the Inflammatory Aspect of Androgenetic Alopecia: A Pilot Study with an Antimicrobial Lotion Journal of Dermatological Treatment · 1996

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    1. The First Broad Replication Study of SNPs and a Pilot Genome-Wide Association Study for Androgenetic Alopecia in Asian Populations Journal of Cosmetic Dermatology · 2022